Camptotheca acuminata (Happy Tree)

Traditional uses

China

  • Cancer

Chemicals

Fruit

  • BETULIC-ACID
  • VINCOSIDE-LACTAM
  • DEOXYCAMPTOTHECIN
  • BETULINIC-ACID

Seed

  • CAMPTOTHECIN — 300

Stem

  • CAMPTOTHECIN — 100

Leaf

  • GALLIC-ACID
  • QUERCETIN
  • TRIFOLIN

Bark

  • 20-HEXANOYLCAMPTOTHECIN
  • 20-HEXANOYL-10-METHOXYCAMPTOTHECIN

Root

  • 10-HYDROXYCAMPTOTHECIN
  • VENOTERPENE
  • TRIMETHYLELLAGIC-ACID

Plant

  • 11-HYDROXYCAMPTOTHECIN

Activities

  1. Anticarcinomic — 4 compounds; toxic activity; 10-HYDROXYCAMPTOTHECIN, BETULINIC-ACID, CAMPTOTHECIN, GALLIC-ACID
  2. Antileukemic — 4 compounds; 10-HYDROXYCAMPTOTHECIN, BETULINIC-ACID, CAMPTOTHECIN, QUERCETIN
  3. Antimelanomic — 4 compounds; 10-HYDROXYCAMPTOTHECIN, BETULINIC-ACID, CAMPTOTHECIN, QUERCETIN
  4. Antitumor — 4 compounds; 10-HYDROXYCAMPTOTHECIN, BETULINIC-ACID, GALLIC-ACID, QUERCETIN
  5. Antiviral — 4 compounds; BETULINIC-ACID, CAMPTOTHECIN, GALLIC-ACID, QUERCETIN
  6. Topoisomerase-I-Inhibitor — 4 compounds; 10-HYDROXYCAMPTOTHECIN, CAMPTOTHECIN, GALLIC-ACID, QUERCETIN
  7. Antibacterial — 3 compounds; BETULINIC-ACID, GALLIC-ACID, QUERCETIN
  8. Anticancer — 3 compounds; 10-HYDROXYCAMPTOTHECIN, BETULINIC-ACID, GALLIC-ACID
  9. Antiherpetic — 3 compounds; CAMPTOTHECIN, GALLIC-ACID, QUERCETIN
  10. AntiHIV — 3 compounds; BETULINIC-ACID, GALLIC-ACID, QUERCETIN
  11. Antiinflammatory — 3 compounds; BETULINIC-ACID, GALLIC-ACID, QUERCETIN
  12. Antitumor (Breast) — 3 compounds; 10-HYDROXYCAMPTOTHECIN, CAMPTOTHECIN, QUERCETIN
  13. Antitumor (Colon) — 3 compounds; 10-HYDROXYCAMPTOTHECIN, CAMPTOTHECIN, QUERCETIN
  14. Antitumor (Lung) — 3 compounds; 10-HYDROXYCAMPTOTHECIN, CAMPTOTHECIN, QUERCETIN
  15. Apoptotic — 3 compounds; BETULINIC-ACID, GALLIC-ACID, QUERCETIN
  16. Cytotoxic — 3 compounds; toxic activity; BETULINIC-ACID, GALLIC-ACID, QUERCETIN
  17. Pesticide — 3 compounds; CAMPTOTHECIN, GALLIC-ACID, QUERCETIN
  18. Aldose-Reductase-Inhibitor — 2 compounds; QUERCETIN, TRIFOLIN
  19. Analgesic — 2 compounds; GALLIC-ACID, QUERCETIN
  20. Antianaphylactic — 2 compounds; GALLIC-ACID, QUERCETIN
  21. Antiangiogenic — 2 compounds; GALLIC-ACID, QUERCETIN
  22. Antiasthmatic — 2 compounds; GALLIC-ACID, QUERCETIN
  23. Antiescherichic — 2 compounds; GALLIC-ACID, QUERCETIN
  24. Antiflu — 2 compounds; GALLIC-ACID, QUERCETIN
  25. Antihepatotoxic — 2 compounds; toxic activity; GALLIC-ACID, QUERCETIN
  26. Antileishmanic — 2 compounds; GALLIC-ACID, QUERCETIN
  27. Antimalarial — 2 compounds; BETULINIC-ACID, QUERCETIN
  28. Antimutagenic — 2 compounds; toxic activity; GALLIC-ACID, QUERCETIN
  29. Antinitrosaminic — 2 compounds; GALLIC-ACID, QUERCETIN
  30. Antinociceptive — 2 compounds; BETULINIC-ACID, QUERCETIN
  31. Antioxidant — 2 compounds; GALLIC-ACID, QUERCETIN
  32. Antiperoxidant — 2 compounds; GALLIC-ACID, QUERCETIN
  33. Antiplasmodial — 2 compounds; BETULINIC-ACID, QUERCETIN
  34. Antipolio — 2 compounds; GALLIC-ACID, QUERCETIN
  35. Antipsoriac — 2 compounds; CAMPTOTHECIN, QUERCETIN
  36. Antiradicular — 2 compounds; GALLIC-ACID, QUERCETIN
  37. Antisarcomic — 2 compounds; 10-HYDROXYCAMPTOTHECIN, CAMPTOTHECIN
  38. Antitumor-Promoter — 2 compounds; GALLIC-ACID, QUERCETIN
  39. Bacteristat — 2 compounds; GALLIC-ACID, QUERCETIN
  40. Cancer-Preventive — 2 compounds; GALLIC-ACID, QUERCETIN
  41. Candidicide — 2 compounds; GALLIC-ACID, QUERCETIN
  42. Carcinogenic — 2 compounds; toxic activity; GALLIC-ACID, QUERCETIN
  43. Cyclooxygenase-Inhibitor — 2 compounds; GALLIC-ACID, QUERCETIN
  44. Hemostat — 2 compounds; GALLIC-ACID, QUERCETIN
  45. Hepatoprotective — 2 compounds; toxic activity; GALLIC-ACID, QUERCETIN
  46. NO-Inhibitor — 2 compounds; GALLIC-ACID, QUERCETIN
  47. Prostaglandin-Synthesis-Inhibitor — 2 compounds; BETULINIC-ACID, QUERCETIN
  48. Topoisomerase-II-Inhibitor — 2 compounds; CAMPTOTHECIN, QUERCETIN
  49. Xanthine-Oxidase-Inhibitor — 2 compounds; GALLIC-ACID, QUERCETIN
  50. 11B-HSD-Inhibitor — 1 compounds; QUERCETIN
  51. 5-Lipoxygenase-Inhibitor — 1 compounds; QUERCETIN
  52. ACE-Inhibitor — 1 compounds; GALLIC-ACID
  53. Aldehyde-Oxidase-Inhibitor — 1 compounds; QUERCETIN
  54. Allelochemic — 1 compounds; QUERCETIN
  55. Allergenic — 1 compounds; toxic activity; QUERCETIN
  56. Anthelmintic — 1 compounds; BETULINIC-ACID
  57. Antiadenovirus — 1 compounds; GALLIC-ACID
  58. Antiaflatoxin — 1 compounds; QUERCETIN
  59. Antiaggregant — 1 compounds; QUERCETIN
  60. Antiaging — 1 compounds; QUERCETIN
  61. Antiallergenic — 1 compounds; toxic activity; GALLIC-ACID
  62. Antiallergic — 1 compounds; QUERCETIN
  63. Antialzheimeran — 1 compounds; QUERCETIN
  64. Antiarthritic — 1 compounds; QUERCETIN
  65. Antiatherosclerotic — 1 compounds; QUERCETIN
  66. Antibronchitic — 1 compounds; GALLIC-ACID
  67. Anticarcinomic (Breast) — 1 compounds; toxic activity; QUERCETIN
  68. Anticariogenic — 1 compounds; QUERCETIN
  69. Anticataract — 1 compounds; QUERCETIN
  70. Anticolitic — 1 compounds; QUERCETIN
  71. Anticomplementary — 1 compounds; QUERCETIN
  72. AntiCrohn's — 1 compounds; QUERCETIN
  73. Anticystitic — 1 compounds; QUERCETIN
  74. Antidepressant — 1 compounds; QUERCETIN
  75. Antidermatitic — 1 compounds; toxic activity; QUERCETIN
  76. Antidiabetic — 1 compounds; QUERCETIN
  77. Antiedemic — 1 compounds; BETULINIC-ACID
  78. Antielastase — 1 compounds; QUERCETIN
  79. Antiencephalitic — 1 compounds; QUERCETIN
  80. Antiestrogenic — 1 compounds; QUERCETIN
  81. Antifeedant — 1 compounds; QUERCETIN
  82. Antifibrinolytic — 1 compounds; GALLIC-ACID
  83. Antifibrosarcomic — 1 compounds; QUERCETIN
  84. Antigastric — 1 compounds; QUERCETIN
  85. Antigonadotropic — 1 compounds; QUERCETIN
  86. AntiGTF — 1 compounds; QUERCETIN
  87. Antihistaminic — 1 compounds; QUERCETIN
  88. Antihydrophobic — 1 compounds; QUERCETIN
  89. Antihypertensive — 1 compounds; QUERCETIN
  90. Antileukotriene — 1 compounds; QUERCETIN
  91. Antilipoperoxidant — 1 compounds; QUERCETIN
  92. Antimetastatic — 1 compounds; QUERCETIN
  93. AntiMRSA — 1 compounds; GALLIC-ACID
  94. Antimyocarditic — 1 compounds; QUERCETIN
  95. Antipancreatitic — 1 compounds; QUERCETIN
  96. Antiperiodontal — 1 compounds; QUERCETIN
  97. Antiperiodontitic — 1 compounds; GALLIC-ACID
  98. Antiperistaltic — 1 compounds; QUERCETIN
  99. Antipermeability — 1 compounds; QUERCETIN
  100. Antipharyngitic — 1 compounds; QUERCETIN
  101. Antiplaque — 1 compounds; QUERCETIN
  102. AntiPMS — 1 compounds; QUERCETIN
  103. Antipodriac — 1 compounds; QUERCETIN
  104. Antiproliferant — 1 compounds; QUERCETIN
  105. Antiprostanoid — 1 compounds; QUERCETIN
  106. Antiprostatitic — 1 compounds; QUERCETIN
  107. Antiproteolytic — 1 compounds; GALLIC-ACID
  108. Antiseptic — 1 compounds; GALLIC-ACID
  109. Antispasmodic — 1 compounds; QUERCETIN
  110. Antistaphylococcic — 1 compounds; GALLIC-ACID
  111. Antistreptococcic — 1 compounds; QUERCETIN
  112. Antithiamin — 1 compounds; QUERCETIN
  113. Antithrombic — 1 compounds; QUERCETIN
  114. Antitrypanosomic — 1 compounds; QUERCETIN
  115. Antitumor (Bladder) — 1 compounds; QUERCETIN
  116. Antitumor (Ovary) — 1 compounds; QUERCETIN
  117. Antitumor (Skin) — 1 compounds; QUERCETIN
  118. Antiulcer — 1 compounds; QUERCETIN
  119. Astringent — 1 compounds; GALLIC-ACID
  120. ATPase-Inhibitor — 1 compounds; QUERCETIN
  121. Bradycardiac — 1 compounds; QUERCETIN
  122. Bronchodilator — 1 compounds; GALLIC-ACID
  123. Calmodulin-Antagonist — 1 compounds; QUERCETIN
  124. cAMP-Phosphodiesterase-Inhibitor — 1 compounds; QUERCETIN
  125. Capillariprotective — 1 compounds; QUERCETIN
  126. Catabolic — 1 compounds; QUERCETIN
  127. Choleretic — 1 compounds; GALLIC-ACID
  128. COMT-Inhibitor — 1 compounds; QUERCETIN
  129. Copper-Chelator — 1 compounds; QUERCETIN
  130. COX-2-Inhibitor — 1 compounds; QUERCETIN
  131. Cytochrome-P450-1A2-Inhibitor — 1 compounds; QUERCETIN
  132. Deiodinase-Inhibitor — 1 compounds; QUERCETIN
  133. Diaphoretic? — 1 compounds; QUERCETIN
  134. Differentiator — 1 compounds; QUERCETIN
  135. Estrogenic — 1 compounds; QUERCETIN
  136. Floral-Inhibitor — 1 compounds; GALLIC-ACID
  137. Fungicide — 1 compounds; QUERCETIN
  138. Glucosyl-Transferase-Inhibitor — 1 compounds; QUERCETIN
  139. Gram(-)icide — 1 compounds; GALLIC-ACID
  140. Gram(+)icide — 1 compounds; GALLIC-ACID
  141. Hepatomagenic — 1 compounds; toxic activity; QUERCETIN
  142. HIV-RT-Inhibitor — 1 compounds; QUERCETIN
  143. Hypoglycemic — 1 compounds; QUERCETIN
  144. Immunomodulator — 1 compounds; GALLIC-ACID
  145. Immunostimulant — 1 compounds; GALLIC-ACID
  146. Immunosuppressant — 1 compounds; GALLIC-ACID
  147. iNOS-Inhibitor — 1 compounds; QUERCETIN
  148. Inotropic — 1 compounds; QUERCETIN
  149. Insecticide — 1 compounds; CAMPTOTHECIN
  150. Insulin-Sparing — 1 compounds; GALLIC-ACID
  151. Insulinogenic — 1 compounds; QUERCETIN
  152. Interferonogenic — 1 compounds; CAMPTOTHECIN
  153. Juvabional — 1 compounds; QUERCETIN
  154. Larvistat — 1 compounds; QUERCETIN
  155. Lipoxygenase-Inhibitor — 1 compounds; QUERCETIN
  156. MAO-A-Inhibitor — 1 compounds; QUERCETIN
  157. Mast-Cell-Stabilizer — 1 compounds; QUERCETIN
  158. Metal-Chelator (Copper) — 1 compounds; QUERCETIN
  159. Metalloproteinase-Inhibitor — 1 compounds; QUERCETIN
  160. MMP-9-Inhibitor — 1 compounds; QUERCETIN
  161. Mutagenic — 1 compounds; toxic activity; QUERCETIN
  162. Myorelaxant — 1 compounds; GALLIC-ACID
  163. NADH-Oxidase-Inhibitor — 1 compounds; QUERCETIN
  164. NEP-Inhibitor — 1 compounds; QUERCETIN
  165. Nephrotoxic — 1 compounds; toxic activity; GALLIC-ACID
  166. Neuroprotective — 1 compounds; toxic activity; QUERCETIN
  167. NF-kB-Inhibitor — 1 compounds; QUERCETIN
  168. NO-Synthase-Inhibitor — 1 compounds; QUERCETIN
  169. Ornithine-Decarboxylase-Inhibitor — 1 compounds; QUERCETIN
  170. P450-Inducer — 1 compounds; QUERCETIN
  171. P450-Inhibitor — 1 compounds; QUERCETIN
  172. PGE2-Inhibitor — 1 compounds; QUERCETIN
  173. Phospholipase-A2-Inhibitor — 1 compounds; BETULINIC-ACID
  174. Phospholipase-Inhibitor — 1 compounds; QUERCETIN
  175. Plasmodicide — 1 compounds; QUERCETIN
  176. Proliferant — 1 compounds; QUERCETIN
  177. Protein-Kinase-C-Inhibitor — 1 compounds; QUERCETIN
  178. PTK-Inhibitor — 1 compounds; QUERCETIN
  179. Quinone-Reductase-Inducer — 1 compounds; QUERCETIN
  180. Styptic — 1 compounds; GALLIC-ACID
  181. Teratologic — 1 compounds; toxic activity; QUERCETIN
  182. TNF-alpha-Inhibitor — 1 compounds; QUERCETIN
  183. Topoisomerase-I-Poison — 1 compounds; toxic activity; CAMPTOTHECIN
  184. Tumorigenic — 1 compounds; QUERCETIN
  185. Tyrosinase-Inhibitor — 1 compounds; QUERCETIN
  186. Tyrosine-Kinase-Inhibitor — 1 compounds; QUERCETIN
  187. Vasodilator — 1 compounds; QUERCETIN
  188. VEGF-Inhibitor — 1 compounds; QUERCETIN

Toxic compounds

  • 10-HYDROXYCAMPTOTHECIN — Anticarcinomic; Root
  • BETULINIC-ACID — Anticarcinomic; Fruit
  • BETULINIC-ACID — Cytotoxic; Fruit; 50-100 ppm
  • CAMPTOTHECIN — Anticarcinomic; Seed; 70 ppb
  • CAMPTOTHECIN — Anticarcinomic; Stem; 70 ppb
  • CAMPTOTHECIN — Topoisomerase-I-Poison; Seed
  • CAMPTOTHECIN — Topoisomerase-I-Poison; Stem
  • GALLIC-ACID — Antiallergenic; Leaf
  • GALLIC-ACID — Anticarcinomic; Leaf; ED50=3
  • GALLIC-ACID — Antihepatotoxic; Leaf
  • GALLIC-ACID — Antimutagenic; Leaf
  • GALLIC-ACID — Carcinogenic; Leaf
  • GALLIC-ACID — Cytotoxic; Leaf; 500 uM
  • GALLIC-ACID — Hepatoprotective; Leaf
  • GALLIC-ACID — Nephrotoxic; Leaf
  • QUERCETIN — Allergenic; Leaf
  • QUERCETIN — Anticarcinomic (Breast); Leaf; IC50=1.5 uM
  • QUERCETIN — Antidermatitic; Leaf
  • QUERCETIN — Antihepatotoxic; Leaf
  • QUERCETIN — Antimutagenic; Leaf; ID50=2-5 nM
  • QUERCETIN — Carcinogenic; Leaf; 40,000 ppm (diet) mus
  • QUERCETIN — Cytotoxic; Leaf; ED50=70 ug/ml
  • QUERCETIN — Hepatomagenic; Leaf; 5,000 ppm (diet) rat
  • QUERCETIN — Hepatoprotective; Leaf
  • QUERCETIN — Mutagenic; Leaf
  • QUERCETIN — Neuroprotective; Leaf; 5-25 uM
  • QUERCETIN — Teratologic; Leaf