Collinsonia canadensis (Stone Root)

Traditional uses

US(Appalachia)

  • Ache(Head)
  • Wound
  • Medicine
  • Dyspepsia
  • Spasm

Elsewhere

  • Colic
  • Diaphoretic
  • Diuretic
  • Dropsy

Turkey

  • Diuretic
  • Sedative
  • Spasm
  • Stomachic
  • Astringent
  • Sudorific
  • Tonic

US

  • Piles
  • Dropsy
  • Respiratory

Chemicals

Plant

  • BETA-ELEMENE — 16
  • EO — 500
  • GERMACRENE-D — 230
  • ALPHA-NAGITANINE — 8
  • ELEMICIN — 18
  • DELTA-CADINENE — 13
  • CARYOPHYLLENE — 2 to 6
  • MUCILAGE
  • TANNIN
  • LIMONENE
  • ALPHA-PINENE
  • BETA-PINENE
  • ROSMARINIC-ACID

Root

  • AKEBOSIDE
  • COLLINSONIDIN
  • COLLINSOGENIN
  • COLLINSONIN
  • HEDERAGENIN-3-O-ALPHA-ARABINOPYRANOSIDE
  • 16-ALPHA-HYDROXYHEDERAGENIN

Activities

  1. Pesticide — 12 compounds; AKEBOSIDE, ALPHA-PINENE, BETA-PINENE, CARYOPHYLLENE, COLLINSONIDIN, COLLINSONIN, DELTA-CADINENE, ELEMICIN, GERMACRENE-D, LIMONENE, ROSMARINIC-ACID, TANNIN
  2. Antibacterial — 6 compounds; ALPHA-PINENE, CARYOPHYLLENE, DELTA-CADINENE, LIMONENE, ROSMARINIC-ACID, TANNIN
  3. Antiinflammatory — 5 compounds; ALPHA-PINENE, BETA-PINENE, CARYOPHYLLENE, LIMONENE, ROSMARINIC-ACID
  4. Cancer-Preventive — 5 compounds; ALPHA-PINENE, LIMONENE, MUCILAGE, ROSMARINIC-ACID, TANNIN
  5. Fungicide — 5 compounds; AKEBOSIDE, CARYOPHYLLENE, COLLINSONIDIN, COLLINSONIN, ELEMICIN
  6. Insectifuge — 5 compounds; ALPHA-PINENE, BETA-PINENE, CARYOPHYLLENE, ELEMICIN, LIMONENE
  7. Allergenic — 4 compounds; toxic activity; ALPHA-PINENE, BETA-PINENE, CARYOPHYLLENE, LIMONENE
  8. Antifeedant — 4 compounds; ALPHA-PINENE, CARYOPHYLLENE, ELEMICIN, LIMONENE
  9. Antispasmodic — 4 compounds; ALPHA-PINENE, BETA-PINENE, CARYOPHYLLENE, LIMONENE
  10. Antiviral — 4 compounds; ALPHA-PINENE, LIMONENE, ROSMARINIC-ACID, TANNIN
  11. FLavor — 4 compounds; ALPHA-PINENE, BETA-PINENE, CARYOPHYLLENE, LIMONENE
  12. Irritant — 4 compounds; toxic activity; ALPHA-PINENE, BETA-PINENE, CARYOPHYLLENE, LIMONENE
  13. Aldose-Reductase-Inhibitor — 3 compounds; CARYOPHYLLENE, DELTA-CADINENE, ROSMARINIC-ACID
  14. Antiacne — 3 compounds; ALPHA-PINENE, CARYOPHYLLENE, DELTA-CADINENE
  15. Anticariogenic — 3 compounds; CARYOPHYLLENE, DELTA-CADINENE, TANNIN
  16. Antimutagenic — 3 compounds; toxic activity; LIMONENE, ROSMARINIC-ACID, TANNIN
  17. Antiproliferant — 3 compounds; BETA-ELEMENE, CARYOPHYLLENE, ROSMARINIC-ACID
  18. Antiseptic — 3 compounds; ALPHA-PINENE, BETA-PINENE, LIMONENE
  19. Antitumor — 3 compounds; CARYOPHYLLENE, LIMONENE, TANNIN
  20. Apoptotic — 3 compounds; BETA-ELEMENE, LIMONENE, ROSMARINIC-ACID
  21. Herbicide — 3 compounds; ALPHA-PINENE, BETA-PINENE, LIMONENE
  22. Insecticide — 3 compounds; ALPHA-PINENE, ELEMICIN, LIMONENE
  23. Perfumery — 3 compounds; ALPHA-PINENE, BETA-PINENE, CARYOPHYLLENE
  24. Sedative — 3 compounds; ALPHA-PINENE, CARYOPHYLLENE, LIMONENE
  25. Transdermal — 3 compounds; ALPHA-PINENE, BETA-PINENE, LIMONENE
  26. Allelochemic — 2 compounds; ALPHA-PINENE, LIMONENE
  27. Antiaggregant — 2 compounds; ELEMICIN, ROSMARINIC-ACID
  28. Antiasthmatic — 2 compounds; CARYOPHYLLENE, LIMONENE
  29. Anticancer — 2 compounds; LIMONENE, TANNIN
  30. Antidepressant — 2 compounds; ELEMICIN, ROSMARINIC-ACID
  31. Antiedemic — 2 compounds; CARYOPHYLLENE, ROSMARINIC-ACID
  32. Antiflu — 2 compounds; ALPHA-PINENE, LIMONENE
  33. Antihepatotoxic — 2 compounds; toxic activity; ROSMARINIC-ACID, TANNIN
  34. AntiHIV — 2 compounds; ROSMARINIC-ACID, TANNIN
  35. Antinephritic — 2 compounds; ROSMARINIC-ACID, TANNIN
  36. Antioxidant — 2 compounds; ROSMARINIC-ACID, TANNIN
  37. Antiradicular — 2 compounds; ROSMARINIC-ACID, TANNIN
  38. Antistaphylococcic — 2 compounds; ALPHA-PINENE, CARYOPHYLLENE
  39. Antistreptococcic — 2 compounds; CARYOPHYLLENE, DELTA-CADINENE
  40. Antiulcer — 2 compounds; CARYOPHYLLENE, TANNIN
  41. Candidicide — 2 compounds; BETA-PINENE, CARYOPHYLLENE
  42. Expectorant — 2 compounds; ALPHA-PINENE, LIMONENE
  43. Immunomodulator — 2 compounds; LIMONENE, ROSMARINIC-ACID
  44. Larvicide — 2 compounds; CARYOPHYLLENE, ELEMICIN
  45. Lipoxygenase-Inhibitor — 2 compounds; ROSMARINIC-ACID, TANNIN
  46. Ornithine-Decarboxylase-Inhibitor — 2 compounds; LIMONENE, TANNIN
  47. P450-Inducer — 2 compounds; DELTA-CADINENE, LIMONENE
  48. Spasmogenic — 2 compounds; ALPHA-PINENE, BETA-PINENE
  49. ABeta-Inhibitor — 1 compounds; ROSMARINIC-ACID
  50. Acaricide — 1 compounds; LIMONENE
  51. AChE-Inhibitor — 1 compounds; LIMONENE
  52. Adenylate-Cyclase-Inhibitor — 1 compounds; ROSMARINIC-ACID
  53. Analgesic — 1 compounds; CARYOPHYLLENE
  54. Anthelmintic — 1 compounds; TANNIN
  55. Antiacetylcholinesterase — 1 compounds; LIMONENE
  56. Antiadenomic — 1 compounds; LIMONENE
  57. Antiallergic — 1 compounds; ROSMARINIC-ACID
  58. Antialzheimeran — 1 compounds; ROSMARINIC-ACID
  59. Antialzheimeran? — 1 compounds; LIMONENE
  60. Antianaphylactic — 1 compounds; ROSMARINIC-ACID
  61. Antiatherosclerotic — 1 compounds; ROSMARINIC-ACID
  62. Anticancer (Cervix) — 1 compounds; BETA-ELEMENE
  63. Anticoagulant — 1 compounds; ROSMARINIC-ACID
  64. Anticomplementary — 1 compounds; ROSMARINIC-ACID
  65. Antidermatitic — 1 compounds; toxic activity; CARYOPHYLLENE
  66. Antidiarrheic — 1 compounds; TANNIN
  67. Antidysenteric — 1 compounds; TANNIN
  68. Antiesophagitic — 1 compounds; LIMONENE
  69. Antigliomic — 1 compounds; BETA-ELEMENE
  70. Antigonadotropic — 1 compounds; ROSMARINIC-ACID
  71. Antihemolytic — 1 compounds; ROSMARINIC-ACID
  72. Antiherpetic — 1 compounds; ROSMARINIC-ACID
  73. Antihistaminic — 1 compounds; ELEMICIN
  74. Antihypertensive — 1 compounds; TANNIN
  75. Antihyperthyroid — 1 compounds; ROSMARINIC-ACID
  76. Antiintegrase — 1 compounds; ROSMARINIC-ACID
  77. Antileishmanic — 1 compounds; CARYOPHYLLENE
  78. Antileukotriene — 1 compounds; ROSMARINIC-ACID
  79. Antilipolytic — 1 compounds; TANNIN
  80. Antilipoperoxidant — 1 compounds; ROSMARINIC-ACID
  81. Antilithic — 1 compounds; LIMONENE
  82. Antilymphomic — 1 compounds; LIMONENE
  83. Antimetastatic (Stomach) — 1 compounds; LIMONENE
  84. Antiobesity — 1 compounds; LIMONENE
  85. Antionychyotic — 1 compounds; CARYOPHYLLENE
  86. Antiophidic — 1 compounds; TANNIN
  87. Antioxidant (LDL) — 1 compounds; ROSMARINIC-ACID
  88. Antiplaque — 1 compounds; ROSMARINIC-ACID
  89. Antipneumonic — 1 compounds; ALPHA-PINENE
  90. Antiprostaglandin — 1 compounds; ROSMARINIC-ACID
  91. Antiproteolytic — 1 compounds; ROSMARINIC-ACID
  92. Antipulmonotic — 1 compounds; ROSMARINIC-ACID
  93. Antirenitic — 1 compounds; TANNIN
  94. Antiserotonic — 1 compounds; ELEMICIN
  95. Antishock — 1 compounds; ROSMARINIC-ACID
  96. Antistress — 1 compounds; ELEMICIN
  97. Antithyreotropic — 1 compounds; ROSMARINIC-ACID
  98. Antithyroid — 1 compounds; ROSMARINIC-ACID
  99. Antitumor (Breast) — 1 compounds; LIMONENE
  100. Antitumor (Cervix) — 1 compounds; BETA-ELEMENE
  101. Antitumor (Colon) — 1 compounds; LIMONENE
  102. Antitumor (Pancreas) — 1 compounds; LIMONENE
  103. Antitumor (Prostate) — 1 compounds; LIMONENE
  104. Antitumor (Stomach) — 1 compounds; LIMONENE
  105. Antitumor-Promoter — 1 compounds; TANNIN
  106. Antiuremic — 1 compounds; ROSMARINIC-ACID
  107. Anxiolytic — 1 compounds; ROSMARINIC-ACID
  108. Bronchoprotectant — 1 compounds; LIMONENE
  109. Calcium-Antagonist — 1 compounds; ROSMARINIC-ACID
  110. Candidistat — 1 compounds; LIMONENE
  111. Carcinogenic — 1 compounds; toxic activity; TANNIN
  112. Chelator — 1 compounds; TANNIN
  113. Chemopreventive — 1 compounds; LIMONENE
  114. Cholesterolytic — 1 compounds; LIMONENE
  115. Coleoptophile — 1 compounds; ALPHA-PINENE
  116. COX-1-Inhibitor — 1 compounds; ROSMARINIC-ACID
  117. COX-2-Inhibitor — 1 compounds; ROSMARINIC-ACID
  118. Cyclooxygenase-Inhibitor — 1 compounds; TANNIN
  119. Cytochrome-P450-Inducer — 1 compounds; DELTA-CADINENE
  120. Cytotoxic — 1 compounds; toxic activity; ROSMARINIC-ACID
  121. Deiodinase-Inhibitor — 1 compounds; ROSMARINIC-ACID
  122. Demulcent — 1 compounds; MUCILAGE
  123. Detoxicant — 1 compounds; toxic activity; LIMONENE
  124. DNA-Binder — 1 compounds; ELEMICIN
  125. Enterocontractant — 1 compounds; LIMONENE
  126. Fungiphilic — 1 compounds; LIMONENE
  127. Fungistat — 1 compounds; LIMONENE
  128. Gastroprotective — 1 compounds; CARYOPHYLLENE
  129. Glucosyl-Transferase-Inhibitor — 1 compounds; TANNIN
  130. GST-Inducer — 1 compounds; LIMONENE
  131. Hallucinogenic — 1 compounds; ELEMICIN
  132. Hepatoprotective — 1 compounds; toxic activity; TANNIN
  133. Histaminic — 1 compounds; LIMONENE
  134. Hypocholesterolemic — 1 compounds; MUCILAGE
  135. Hypotensive — 1 compounds; ELEMICIN
  136. Immunostimulant — 1 compounds; ROSMARINIC-ACID
  137. Immunosuppressant — 1 compounds; TANNIN
  138. Insectiphile — 1 compounds; ALPHA-PINENE
  139. Interleukin-6-Inhibitor — 1 compounds; LIMONENE
  140. Lipolytic — 1 compounds; LIMONENE
  141. MAO-Inhibitor — 1 compounds; TANNIN
  142. Mosquitocide — 1 compounds; CARYOPHYLLENE
  143. Myorelaxant — 1 compounds; LIMONENE
  144. Nematicide — 1 compounds; LIMONENE
  145. Neuroprotective — 1 compounds; toxic activity; ROSMARINIC-ACID
  146. Neurotoxic — 1 compounds; toxic activity; ELEMICIN
  147. NO-Genic — 1 compounds; LIMONENE
  148. Ozone-Scavenger — 1 compounds; LIMONENE
  149. P450-2B1-Inhibitor — 1 compounds; ALPHA-PINENE
  150. Peristaltic — 1 compounds; LIMONENE
  151. Pheromone — 1 compounds; GERMACRENE-D
  152. Photosensitizer — 1 compounds; LIMONENE
  153. Psychotropic — 1 compounds; TANNIN
  154. Radioprotective — 1 compounds; ROSMARINIC-ACID
  155. Schistosomicide — 1 compounds; ELEMICIN
  156. Termitifuge — 1 compounds; CARYOPHYLLENE
  157. Testosterone-Inducer — 1 compounds; DELTA-CADINENE
  158. Tranquilizer — 1 compounds; ALPHA-PINENE
  159. Xanthine-Oxidase-Inhibitor — 1 compounds; TANNIN

Toxic compounds

  • ALPHA-PINENE — Allergenic; Plant
  • ALPHA-PINENE — Irritant; Plant
  • BETA-PINENE — Allergenic; Plant
  • BETA-PINENE — Irritant; Plant
  • CARYOPHYLLENE — Allergenic; Plant
  • CARYOPHYLLENE — Antidermatitic; Plant
  • CARYOPHYLLENE — Irritant; Plant
  • ELEMICIN — Neurotoxic; Plant
  • LIMONENE — Allergenic; Plant; 1/20th carene
  • LIMONENE — Antimutagenic; Plant
  • LIMONENE — Detoxicant; Plant
  • LIMONENE — Irritant; Plant
  • ROSMARINIC-ACID — Antihepatotoxic; Plant
  • ROSMARINIC-ACID — Antimutagenic; Plant
  • ROSMARINIC-ACID — Cytotoxic; Plant; TC50=100-150 ug/ml
  • ROSMARINIC-ACID — Neuroprotective; Plant
  • TANNIN — Antihepatotoxic; Plant
  • TANNIN — Antimutagenic; Plant
  • TANNIN — Carcinogenic; Plant
  • TANNIN — Hepatoprotective; Plant