Mitragyna speciosa (Kratum)

Traditional uses

Malaya

  • Delirium
  • Fever

Java

  • Fumitory
  • Narcotic

Asia

  • Fumitory
  • Masticatory
  • Sedative

Perak

  • Splenomegaly
  • Vermifuge
  • Wound

Chemicals

Leaf

  • AJMALICINE
  • CORYNANTHEIDALINE
  • 3-DEHYDROMITRAGYNINE — 36
  • MITRAPHYLLINE
  • RHYNCHOPHYLLINE
  • SPECIOFOLINE
  • SPECIOGYNINE — 44
  • SPECIOPHYLLINE
  • CORYNANTHEIDINE
  • ISOMITRAPHYLLINE
  • MITRAGYNINE — 86
  • MITRAGYNALINE
  • SPECIOCILIATINE — 30
  • STIPULATINE
  • PAYNANTHEINE — 50
  • MITRACILIATINE — 32
  • (-)-EPICATECHIN — 150

Plant

  • ISOMITRAFOLINE
  • ISOSPECIOFOLINE
  • ROTUNDIFOLINE
  • UNCARINE-D
  • MITRAGYNOL
  • MITRAVERSINE

Seed

  • MITRASPECINE

Activities

  1. Antileukemic — 4 compounds; (-)-EPICATECHIN, ISOMITRAPHYLLINE, MITRAPHYLLINE, SPECIOPHYLLINE
  2. Hypotensive — 4 compounds; AJMALICINE, MITRAGYNINE, MITRAPHYLLINE, RHYNCHOPHYLLINE
  3. Vasodilator — 4 compounds; (-)-EPICATECHIN, MITRAGYNINE, MITRAPHYLLINE, RHYNCHOPHYLLINE
  4. Anesthetic — 3 compounds; MITRAGYNINE, MITRAPHYLLINE, RHYNCHOPHYLLINE
  5. Antiaggregant — 3 compounds; (-)-EPICATECHIN, AJMALICINE, RHYNCHOPHYLLINE
  6. Antihypertensive — 3 compounds; AJMALICINE, MITRAPHYLLINE, RHYNCHOPHYLLINE
  7. Immunostimulant — 3 compounds; (-)-EPICATECHIN, ISOMITRAPHYLLINE, MITRAPHYLLINE
  8. Analgesic — 2 compounds; MITRAGYNINE, SPECIOCILIATINE
  9. Antioxidant — 2 compounds; (-)-EPICATECHIN, RHYNCHOPHYLLINE
  10. Cardiodepressant — 2 compounds; toxic activity; MITRAPHYLLINE, RHYNCHOPHYLLINE
  11. CNS-Depressant — 2 compounds; AJMALICINE, MITRAPHYLLINE
  12. Cytotoxic — 2 compounds; toxic activity; (-)-EPICATECHIN, UNCARINE-D
  13. Myocontractant — 2 compounds; MITRAPHYLLINE, RHYNCHOPHYLLINE
  14. Myorelaxant — 2 compounds; MITRAGYNINE, MITRAPHYLLINE
  15. Pesticide — 2 compounds; (-)-EPICATECHIN, MITRAPHYLLINE
  16. Protisticide — 2 compounds; MITRAPHYLLINE, RHYNCHOPHYLLINE
  17. 5-Lipoxygenase-Inhibitor — 1 compounds; (-)-EPICATECHIN
  18. ACE-Inhibitor — 1 compounds; (-)-EPICATECHIN
  19. Adrenolytic — 1 compounds; AJMALICINE
  20. Allelochemic — 1 compounds; (-)-EPICATECHIN
  21. Antiadrenergic — 1 compounds; AJMALICINE
  22. Antianaphylactic — 1 compounds; (-)-EPICATECHIN
  23. Antibacterial — 1 compounds; (-)-EPICATECHIN
  24. Antidementia — 1 compounds; RHYNCHOPHYLLINE
  25. Antidiabetic — 1 compounds; (-)-EPICATECHIN
  26. Antidiuretic — 1 compounds; AJMALICINE
  27. AntiEBV — 1 compounds; (-)-EPICATECHIN
  28. Antiexcitotoxic — 1 compounds; toxic activity; RHYNCHOPHYLLINE
  29. Antihepatitic — 1 compounds; (-)-EPICATECHIN
  30. AntiHIV — 1 compounds; (-)-EPICATECHIN
  31. Antihyperglycemic — 1 compounds; (-)-EPICATECHIN
  32. Antiinflammatory — 1 compounds; (-)-EPICATECHIN
  33. Antiischemic — 1 compounds; RHYNCHOPHYLLINE
  34. Antileukotriene — 1 compounds; (-)-EPICATECHIN
  35. Antilipoperoxidant — 1 compounds; (-)-EPICATECHIN
  36. Antimutagenic — 1 compounds; toxic activity; (-)-EPICATECHIN
  37. Antiperoxidant — 1 compounds; (-)-EPICATECHIN
  38. Antipyretic — 1 compounds; RHYNCHOPHYLLINE
  39. Antiradicular — 1 compounds; RHYNCHOPHYLLINE
  40. Antithrombotic — 1 compounds; RHYNCHOPHYLLINE
  41. Antitussive — 1 compounds; SPECIOCILIATINE
  42. Antiviral — 1 compounds; (-)-EPICATECHIN
  43. Beta-Adrenergic Receptor Blocker — 1 compounds; (-)-EPICATECHIN
  44. Calcium-Antagonist — 1 compounds; RHYNCHOPHYLLINE
  45. Calcium-Blocker — 1 compounds; RHYNCHOPHYLLINE
  46. Cancer-Preventive — 1 compounds; (-)-EPICATECHIN
  47. Cardiotonic — 1 compounds; toxic activity; (-)-EPICATECHIN
  48. Cerebrocirculant — 1 compounds; AJMALICINE
  49. Choline-Sparing — 1 compounds; (-)-EPICATECHIN
  50. Circulotonic — 1 compounds; AJMALICINE
  51. CNS-Stimulant — 1 compounds; MITRAGYNINE
  52. COMP-Inhibitor — 1 compounds; (-)-EPICATECHIN
  53. Dopaminergic — 1 compounds; RHYNCHOPHYLLINE
  54. Febrifuge — 1 compounds; RHYNCHOPHYLLINE
  55. Hypocholesterolemic — 1 compounds; (-)-EPICATECHIN
  56. Hypoglycemic — 1 compounds; (-)-EPICATECHIN
  57. Insulinogenic — 1 compounds; (-)-EPICATECHIN
  58. Lipoxygenase-1-Inhibitor — 1 compounds; (-)-EPICATECHIN
  59. Lipoxygenase-Inhibitor — 1 compounds; (-)-EPICATECHIN
  60. Neuroparalytic — 1 compounds; toxic activity; RHYNCHOPHYLLINE
  61. Pancreatogenic — 1 compounds; (-)-EPICATECHIN
  62. Phagocytotic — 1 compounds; ISOMITRAPHYLLINE
  63. Reverse-Transcriptase-Inhibitor — 1 compounds; (-)-EPICATECHIN
  64. Sedative — 1 compounds; RHYNCHOPHYLLINE
  65. Serotonergic — 1 compounds; RHYNCHOPHYLLINE
  66. Sympatholytic — 1 compounds; AJMALICINE
  67. Tranquilizer — 1 compounds; AJMALICINE
  68. Uterotonic — 1 compounds; RHYNCHOPHYLLINE
  69. Xanthine-Oxidase-Inhibitor — 1 compounds; (-)-EPICATECHIN

Toxic compounds

  • (-)-EPICATECHIN — Antimutagenic; Leaf
  • (-)-EPICATECHIN — Cardiotonic; Leaf
  • (-)-EPICATECHIN — Cytotoxic; Leaf; TC50=>100 ug/ml
  • MITRAPHYLLINE — Cardiodepressant; Leaf
  • RHYNCHOPHYLLINE — Antiexcitotoxic; Leaf
  • RHYNCHOPHYLLINE — Cardiodepressant; Leaf
  • RHYNCHOPHYLLINE — Neuroparalytic; Leaf
  • UNCARINE-D — Cytotoxic; Plant; ED50=36