Phyllanthus amarus

Traditional uses

Haiti

  • Diabetes
  • Malaria
  • Digestive
  • Diuretic

Trinidad

  • Venereal
  • Oliguria

Polynesia

  • Piscicide

Chemicals

Shoot

  • HYPOPHYLLANTHIN — 59.4 to 59
  • REPANDUSINIC ACID B
  • RUTIN — 1378.3 to 1378
  • AMARIIN — 100 to 1000
  • AMARIINIC ACID
  • CORILAGIN — 351.3
  • ELAEOCARPUSIN
  • FUROSIN
  • GALLIC-ACID — 864.8 to 865
  • 1-6-DI-GALLOYL-GLUCOPYRANOSE — 18.9 to 19
  • GERANIIN — 10270.2 to 10270
  • GERANIINIC ACID
  • PHYLLANTHIN — 262.2 to 262
  • PHYLLANTHUSIIN D — 162.1 to 162
  • ISOQUERCITRIN — 121.6 to 122
  • 4-O-GALLOYL-QUINIC ACID
  • GALLOCATECHIN — 67.5

Root

  • HYPOPHYLLANTHIN — 30 to 100
  • PHYLLANTHIN — 30 to 120

Stem

  • HYPOPHYLLANTHIN — 160
  • PHYLLANTHIN — 580

Branches

  • HYPOPHYLLANTHIN — 270
  • PHYLLANTHIN — 670

Fruit

  • HYPOPHYLLANTHIN — 40 to 1810
  • PHYLLANTHIN — 170 to 5100

Plant

  • AMARULONE
  • GERANIIN

Leaf

  • HYPOPHYLLANTHIN — 2710
  • PHYLLANTHIN — 7090
  • EPIBUBBIALINE — 100
  • ISOBUBBIALINE — 120
  • PHYLLANTHINE — 260
  • SECURININE — 210
  • NORSECURININE — 180

Activities

  1. Topoisomerase-II-Inhibitor — 6 compounds; CORILAGIN, ELAEOCARPUSIN, FUROSIN, GERANIIN, ISOQUERCITRIN, RUTIN
  2. Antihepatotoxic — 5 compounds; toxic activity; CORILAGIN, GALLIC-ACID, HYPOPHYLLANTHIN, PHYLLANTHIN, RUTIN
  3. Antioxidant — 5 compounds; CORILAGIN, GALLIC-ACID, GERANIIN, ISOQUERCITRIN, RUTIN
  4. Antiradicular — 5 compounds; CORILAGIN, GALLIC-ACID, GERANIIN, ISOQUERCITRIN, RUTIN
  5. Pesticide — 5 compounds; GALLIC-ACID, GERANIIN, ISOQUERCITRIN, RUTIN, SECURININE
  6. ACE-Inhibitor — 4 compounds; CORILAGIN, GALLIC-ACID, GERANIIN, ISOQUERCITRIN
  7. Antibacterial — 4 compounds; GALLIC-ACID, ISOQUERCITRIN, RUTIN, SECURININE
  8. Antiinflammatory — 4 compounds; CORILAGIN, GALLIC-ACID, ISOQUERCITRIN, RUTIN
  9. Antimutagenic — 4 compounds; toxic activity; CORILAGIN, GALLIC-ACID, GERANIIN, RUTIN
  10. Antiperoxidant — 4 compounds; CORILAGIN, GALLIC-ACID, GERANIIN, RUTIN
  11. Antiasthmatic — 3 compounds; CORILAGIN, GALLIC-ACID, GERANIIN
  12. Anticancer — 3 compounds; GALLIC-ACID, ISOQUERCITRIN, RUTIN
  13. Antiherpetic — 3 compounds; GALLIC-ACID, GERANIIN, RUTIN
  14. Antitumor — 3 compounds; GALLIC-ACID, ISOQUERCITRIN, RUTIN
  15. Antitumor-Promoter — 3 compounds; GALLIC-ACID, ISOQUERCITRIN, RUTIN
  16. Antiviral — 3 compounds; GALLIC-ACID, GERANIIN, RUTIN
  17. Cancer-Preventive — 3 compounds; GALLIC-ACID, ISOQUERCITRIN, RUTIN
  18. Xanthine-Oxidase-Inhibitor — 3 compounds; CORILAGIN, GALLIC-ACID, GERANIIN
  19. Aldose-Reductase-Inhibitor — 2 compounds; ISOQUERCITRIN, RUTIN
  20. Antiallergenic — 2 compounds; toxic activity; GALLIC-ACID, GERANIIN
  21. Antiallergic — 2 compounds; CORILAGIN, RUTIN
  22. Antifeedant — 2 compounds; ISOQUERCITRIN, RUTIN
  23. AntiHIV — 2 compounds; GALLIC-ACID, GERANIIN
  24. Antihypertensive — 2 compounds; GERANIIN, RUTIN
  25. Antilipolytic — 2 compounds; CORILAGIN, GERANIIN
  26. Antimalarial — 2 compounds; RUTIN, SECURININE
  27. Antinociceptive — 2 compounds; ISOQUERCITRIN, RUTIN
  28. Apoptotic — 2 compounds; GALLIC-ACID, RUTIN
  29. Hemostat — 2 compounds; GALLIC-ACID, RUTIN
  30. Hepatoprotective — 2 compounds; toxic activity; GALLIC-ACID, RUTIN
  31. Hypotensive — 2 compounds; ISOQUERCITRIN, RUTIN
  32. Immunomodulator — 2 compounds; GALLIC-ACID, RUTIN
  33. Insectiphile — 2 compounds; ISOQUERCITRIN, RUTIN
  34. Juvabional — 2 compounds; GERANIIN, RUTIN
  35. Larvistat — 2 compounds; GERANIIN, RUTIN
  36. Myorelaxant — 2 compounds; GALLIC-ACID, RUTIN
  37. Topoisomerase-I-Inhibitor — 2 compounds; CORILAGIN, GALLIC-ACID
  38. Vasodilator — 2 compounds; GERANIIN, RUTIN
  39. 5-HT-Inhibitor — 1 compounds; RUTIN
  40. Adrenocorticotrophic — 1 compounds; GERANIIN
  41. Aldehyde-Oxidase-Inhibitor — 1 compounds; RUTIN
  42. Allelochemic — 1 compounds; RUTIN
  43. Analgesic — 1 compounds; GALLIC-ACID
  44. Antiadenovirus — 1 compounds; GALLIC-ACID
  45. Antiaggregant — 1 compounds; RUTIN
  46. Antianaphylactic — 1 compounds; GALLIC-ACID
  47. Antiangiogenic — 1 compounds; GALLIC-ACID
  48. Antiapoplectic — 1 compounds; RUTIN
  49. Antiatherogenic — 1 compounds; RUTIN
  50. Antiatherosclerotic — 1 compounds; RUTIN
  51. Antibronchitic — 1 compounds; GALLIC-ACID
  52. Anticapillary-Fragility — 1 compounds; RUTIN
  53. Anticarcinomic — 1 compounds; toxic activity; GALLIC-ACID
  54. Anticataract — 1 compounds; RUTIN
  55. Anticlastogen — 1 compounds; RUTIN
  56. Anticonvulsant — 1 compounds; toxic activity; RUTIN
  57. AntiCVI — 1 compounds; RUTIN
  58. Antidementia — 1 compounds; RUTIN
  59. Antidermatitic — 1 compounds; toxic activity; RUTIN
  60. Antidiabetic — 1 compounds; RUTIN
  61. Antiedemic — 1 compounds; RUTIN
  62. Antielastase — 1 compounds; ISOQUERCITRIN
  63. Antierythemic — 1 compounds; RUTIN
  64. Antiescherichic — 1 compounds; GALLIC-ACID
  65. Antifibrinolytic — 1 compounds; GALLIC-ACID
  66. Antiflu — 1 compounds; GALLIC-ACID
  67. Antiglaucomic — 1 compounds; RUTIN
  68. Antihematuric — 1 compounds; RUTIN
  69. Antihemorrhoidal — 1 compounds; RUTIN
  70. Antihistaminic — 1 compounds; RUTIN
  71. Antileishmanic — 1 compounds; GALLIC-ACID
  72. Antimelanomic — 1 compounds; RUTIN
  73. Antimetastatic — 1 compounds; RUTIN
  74. AntiMRSA — 1 compounds; GALLIC-ACID
  75. AntiMS — 1 compounds; SECURININE
  76. Antinephritic — 1 compounds; RUTIN
  77. Antineurasthenic — 1 compounds; SECURININE
  78. Antinitrosaminic — 1 compounds; GALLIC-ACID
  79. Antiparylytic — 1 compounds; SECURININE
  80. Antiperiodontitic — 1 compounds; GALLIC-ACID
  81. Antiplatelet — 1 compounds; RUTIN
  82. Antipolio — 1 compounds; GALLIC-ACID
  83. Antiproliferant — 1 compounds; RUTIN
  84. Antiproteolytic — 1 compounds; GALLIC-ACID
  85. Antiprotozoal — 1 compounds; RUTIN
  86. Antipurpuric — 1 compounds; RUTIN
  87. Antiseptic — 1 compounds; GALLIC-ACID
  88. Antispasmodic — 1 compounds; RUTIN
  89. Antistaphylococcic — 1 compounds; GALLIC-ACID
  90. Antisunburn — 1 compounds; RUTIN
  91. Antithrombogenic — 1 compounds; RUTIN
  92. Antithyroid — 1 compounds; RUTIN
  93. Antitrypanosomic — 1 compounds; RUTIN
  94. Antiulcer — 1 compounds; RUTIN
  95. Antivaricose — 1 compounds; RUTIN
  96. Astringent — 1 compounds; GALLIC-ACID
  97. Bacteristat — 1 compounds; GALLIC-ACID
  98. Beta-Adrenergic Receptor Blocker — 1 compounds; GERANIIN
  99. Bronchodilator — 1 compounds; GALLIC-ACID
  100. cAMP-Phosphodiesterase-Inhibitor — 1 compounds; RUTIN
  101. Candidicide — 1 compounds; GALLIC-ACID
  102. Capillarigenic — 1 compounds; ISOQUERCITRIN
  103. Capillariprotective — 1 compounds; RUTIN
  104. Carcinogenic — 1 compounds; toxic activity; GALLIC-ACID
  105. Catabolic — 1 compounds; RUTIN
  106. Chemopreventive — 1 compounds; RUTIN
  107. Choleretic — 1 compounds; GALLIC-ACID
  108. CNS-Stimulant — 1 compounds; SECURININE
  109. Cyclooxygenase-Inhibitor — 1 compounds; GALLIC-ACID
  110. Cytoprotective — 1 compounds; RUTIN
  111. Cytotoxic — 1 compounds; toxic activity; GALLIC-ACID
  112. Diaphoretic — 1 compounds; ISOQUERCITRIN
  113. Diuretic — 1 compounds; ISOQUERCITRIN
  114. Estrogenic? — 1 compounds; RUTIN
  115. Floral-Inhibitor — 1 compounds; GALLIC-ACID
  116. Gram(-)icide — 1 compounds; GALLIC-ACID
  117. Gram(+)icide — 1 compounds; GALLIC-ACID
  118. Hepatomagenic — 1 compounds; toxic activity; RUTIN
  119. Hypocholesterolemic — 1 compounds; RUTIN
  120. Immunostimulant — 1 compounds; GALLIC-ACID
  121. Immunosuppressant — 1 compounds; GALLIC-ACID
  122. Insecticide — 1 compounds; RUTIN
  123. Insulin-Sparing — 1 compounds; GALLIC-ACID
  124. Lipoxygenase-Inhibitor — 1 compounds; RUTIN
  125. Mutagenic — 1 compounds; toxic activity; RUTIN
  126. Myoprotective — 1 compounds; RUTIN
  127. Nephrotoxic — 1 compounds; toxic activity; GALLIC-ACID
  128. NO-Inhibitor — 1 compounds; GALLIC-ACID
  129. Oviposition-Stimulant — 1 compounds; RUTIN
  130. PAF-Inhibitor — 1 compounds; RUTIN
  131. Piscicide — 1 compounds; PHYLLANTHIN
  132. Protein-Kinase-Inhibitor — 1 compounds; AMARIIN
  133. Protisticide — 1 compounds; RUTIN
  134. Radioprotective — 1 compounds; RUTIN
  135. Styptic — 1 compounds; GALLIC-ACID
  136. Sunscreen — 1 compounds; RUTIN
  137. TNF-alpha-Inhibitor — 1 compounds; ISOQUERCITRIN
  138. Vasopressor — 1 compounds; RUTIN

Toxic compounds

  • CORILAGIN — Antihepatotoxic; Shoot
  • CORILAGIN — Antimutagenic; Shoot
  • GALLIC-ACID — Antiallergenic; Shoot
  • GALLIC-ACID — Anticarcinomic; Shoot; ED50=3
  • GALLIC-ACID — Antihepatotoxic; Shoot
  • GALLIC-ACID — Antimutagenic; Shoot
  • GALLIC-ACID — Carcinogenic; Shoot
  • GALLIC-ACID — Cytotoxic; Shoot; 500 uM
  • GALLIC-ACID — Hepatoprotective; Shoot
  • GALLIC-ACID — Nephrotoxic; Shoot
  • GERANIIN — Antiallergenic; Plant
  • GERANIIN — Antiallergenic; Shoot
  • GERANIIN — Antimutagenic; Plant
  • GERANIIN — Antimutagenic; Shoot
  • HYPOPHYLLANTHIN — Antihepatotoxic; Branches
  • HYPOPHYLLANTHIN — Antihepatotoxic; Fruit
  • HYPOPHYLLANTHIN — Antihepatotoxic; Leaf
  • HYPOPHYLLANTHIN — Antihepatotoxic; Root
  • HYPOPHYLLANTHIN — Antihepatotoxic; Shoot
  • HYPOPHYLLANTHIN — Antihepatotoxic; Stem
  • PHYLLANTHIN — Antihepatotoxic; Branches
  • PHYLLANTHIN — Antihepatotoxic; Fruit
  • PHYLLANTHIN — Antihepatotoxic; Leaf
  • PHYLLANTHIN — Antihepatotoxic; Root
  • PHYLLANTHIN — Antihepatotoxic; Shoot
  • PHYLLANTHIN — Antihepatotoxic; Stem
  • RUTIN — Anticonvulsant; Shoot
  • RUTIN — Antidermatitic; Shoot
  • RUTIN — Antihepatotoxic; Shoot
  • RUTIN — Antimutagenic; Shoot; ID50=2-5 nM
  • RUTIN — Hepatomagenic; Shoot; 20,000 ppm (diet) rat
  • RUTIN — Hepatoprotective; Shoot; 20 mg/kg rat
  • RUTIN — Mutagenic; Shoot