Rauvolfia vomitoria (African Snakeroot)

Traditional uses

Upper Volta

• Aphrodisiac
• Congestion
• Leprosy
• Emetic
• Bite(Snake)
• Psoriasis

Nigeria

• Bite(Snake)
• Gonorrhea
• Jaundice
• Sedative
• Gastritis
• Enteritis

Ghana

• Convulsion
• Erysipelas
• Herpes
• Measles
• Rheumatism
• Sprain
• Swelling
• Vertigo
• Jaundice
• Urethrum
• Urticaria
• Dislocation
• Purgative

W Africa

• Dyspepsia
• Yaws
• Skin

Liberia

• Fever

Ivory Coast

• Gonorrhea

Africa

• Purgative
• Sedative
• Aphrodisiac
• Skin
• Convulsion
• Emetic
• Erysipelas
• Measles

E Africa

• Pediculicide

Chemicals

Plant

• 17-ACETYL-AJMALINE
• DEACETYLDEFORMYLPICRALINE
• ISOCARAPANAUBINE
• ISOSANDWICENE
• NEONORRESERPINE
• RAUNITIDINE
• RAUVOMILINE
• RENOXIDINE
• VOMILENINE
• ALPHA-YOHIMBINE
• RAUGALLINE
• SERPENTICINE
• DEACETYLDEFORMYLAKUAMMILINE
• PERAKINE
• YOHIMBINE

Root

• AJMALICINE
• AJMALINE
• ISOAJMALINE
• PURPELINE
• RESCINNAMINE
• RESERPOXIDINE
• SARPAGINE
• SEREPENTENINE
• AJMALININE
• MITORIDINE
• RESCIDINE
• RESERPINE
• SERADAMINE
• ALSTONINE
• RAUMITORINE
• RAUVOMITINE
• RESERPILINE
• SEREDINE
• STIGMASTEROL
• VOMALIDENE
• RAUVANINE

Leaf

• ARICINE
• CARAPANAUBINE
• ISORESERPILINE-PSEUDOINDOXYL
• RAUVOXININE
• TETRAHYDROALSTONINE
• VIMIFOLINE
• PICRININE
• RAUVOXINE
• ISORESERPILINE

Activities

1. Antihypertensive — 6 compounds; AJMALICINE, AJMALINE, RESCINNAMINE, RESERPILINE, RESERPINE, YOHIMBINE
2. CNS-Depressant — 5 compounds; AJMALICINE, ISORESERPILINE, PICRININE, RESERPINE, YOHIMBINE
3. Hypotensive — 5 compounds; AJMALICINE, AJMALINE, AJMALININE, ISORESERPILINE, RESERPINE
4. Tranquilizer — 4 compounds; AJMALICINE, AJMALINE, RESCINNAMINE, RESERPINE
5. Adrenolytic — 3 compounds; AJMALICINE, AJMALINE, YOHIMBINE
6. Calcium-Antagonist — 3 compounds; AJMALINE, RESERPINE, YOHIMBINE
7. Sedative — 3 compounds; RESCINNAMINE, RESERPINE, STIGMASTEROL
8. Antiadrenergic — 2 compounds; AJMALICINE, RESERPINE
9. Antidiuretic — 2 compounds; AJMALICINE, YOHIMBINE
10. Cardiotoxic — 2 compounds; toxic activity; AJMALINE, ISORESERPILINE
11. Hypothermic — 2 compounds; RESERPINE, YOHIMBINE
12. MDR-Inhibitor — 2 compounds; RESERPINE, YOHIMBINE
13. Peristaltic — 2 compounds; AJMALINE, RESERPINE
14. Pesticide — 2 compounds; ALSTONINE, ARICINE
15. Sympatholytic — 2 compounds; AJMALICINE, AJMALININE
16. (-)-Chronotropic — 1 compounds; ARICINE
17. Abortifacient — 1 compounds; toxic activity; RESERPINE
18. Adrenergic-Blocker — 1 compounds; YOHIMBINE
19. Allergenic — 1 compounds; toxic activity; AJMALINE
20. Amebicide — 1 compounds; ARICINE
21. Anesthetic — 1 compounds; YOHIMBINE
22. Antiacetylcholinesterase — 1 compounds; YOHIMBINE
23. Antiaggregant — 1 compounds; AJMALICINE
24. Antiamebic — 1 compounds; ALSTONINE
25. Antianginal — 1 compounds; YOHIMBINE
26. Antiarrhythmic — 1 compounds; AJMALINE
27. Antiatherosclerotic — 1 compounds; YOHIMBINE
28. Antibacterial — 1 compounds; ALSTONINE
29. Anticonvulsant — 1 compounds; toxic activity; RESERPINE
30. Antidepressant — 1 compounds; YOHIMBINE
31. Antidopaminergic — 1 compounds; YOHIMBINE
32. Antidote — 1 compounds; YOHIMBINE
33. Antidyskinetic — 1 compounds; RESERPINE
34. Antihepatotoxic — 1 compounds; toxic activity; STIGMASTEROL
35. Antihypertonic — 1 compounds; AJMALINE
36. Antiinflammatory — 1 compounds; STIGMASTEROL
37. Antiketaminic — 1 compounds; YOHIMBINE
38. Antileukemic — 1 compounds; RESERPINE
39. Antimalarial — 1 compounds; ALPHA-YOHIMBINE
40. Antimigraine — 1 compounds; RESERPINE
41. Antineoplastic — 1 compounds; ALSTONINE
42. Antinociceptive — 1 compounds; STIGMASTEROL
43. Antiophidic — 1 compounds; STIGMASTEROL
44. Antioxidant — 1 compounds; STIGMASTEROL
45. Antiparaesthesic — 1 compounds; YOHIMBINE
46. Antiplasmodial — 1 compounds; ALPHA-YOHIMBINE
47. Antipsychotic — 1 compounds; RESERPINE
48. Antipyretic — 1 compounds; RESERPINE
49. AntiRaynaud's — 1 compounds; RESERPINE
50. Antischizophrenic — 1 compounds; RESERPINE
51. Antiserotonin — 1 compounds; YOHIMBINE
52. Antistress — 1 compounds; RESERPINE
53. Antitumor — 1 compounds; RESERPINE
54. Antiviral — 1 compounds; STIGMASTEROL
55. Anxiogenic — 1 compounds; YOHIMBINE
56. Aphrodisiac — 1 compounds; YOHIMBINE
57. Artemicide — 1 compounds; STIGMASTEROL
58. Bradycardic — 1 compounds; RESERPINE
59. Cancer-Preventive — 1 compounds; STIGMASTEROL
60. Cardiodepressant — 1 compounds; toxic activity; AJMALINE
61. Cardiotonic — 1 compounds; toxic activity; YOHIMBINE
62. Cardiovascular — 1 compounds; toxic activity; YOHIMBINE
63. Catecholaminolytic — 1 compounds; RESERPINE
64. Cerebrocirculant — 1 compounds; AJMALICINE
65. Cholinergic — 1 compounds; YOHIMBINE
66. Circulotonic — 1 compounds; AJMALICINE
67. CNS-Stimulant — 1 compounds; YOHIMBINE
68. Convulsant — 1 compounds; toxic activity; AJMALINE
69. Coronary-Dilator — 1 compounds; AJMALINE
70. Cytotoxic — 1 compounds; toxic activity; ARICINE
71. Emetic — 1 compounds; YOHIMBINE
72. Estrogenic — 1 compounds; STIGMASTEROL
73. Fungicide — 1 compounds; ALSTONINE
74. Hepatoprotective — 1 compounds; toxic activity; RESERPINE
75. Hypertensive — 1 compounds; YOHIMBINE
76. Hypocholesterolemic — 1 compounds; STIGMASTEROL
77. Hypoglycemic — 1 compounds; TETRAHYDROALSTONINE
78. MAO-Inhibitor — 1 compounds; YOHIMBINE
79. Mydriatic — 1 compounds; YOHIMBINE
80. Myocardiodepressant — 1 compounds; toxic activity; AJMALINE
81. Nephrovasodilator — 1 compounds; toxic activity; AJMALININE
82. Neurotoxic — 1 compounds; toxic activity; AJMALINE
83. Ovulant — 1 compounds; STIGMASTEROL
84. Parasympathetic — 1 compounds; ISORESERPILINE
85. Respirastimulant — 1 compounds; AJMALINE
86. Respirodepressant — 1 compounds; YOHIMBINE
87. Respirostimulant — 1 compounds; YOHIMBINE
88. Rhinorreic — 1 compounds; YOHIMBINE
89. Rodenticide — 1 compounds; RESERPINE
90. Serotoninolytic — 1 compounds; RESERPINE
91. Sialogogue — 1 compounds; YOHIMBINE
92. Teratogenic — 1 compounds; toxic activity; RESERPINE
93. Tremorigenic — 1 compounds; YOHIMBINE
94. Tumorigenic — 1 compounds; RESERPINE
95. Ulcerogenic — 1 compounds; RESERPINE
96. Uterotonic — 1 compounds; RESERPINE
97. Vasoconstrictor — 1 compounds; RESERPINE

Toxic compounds

• AJMALINE — Allergenic; Root
• AJMALINE — Cardiodepressant; Root
• AJMALINE — Cardiotoxic; Root
• AJMALINE — Convulsant; Root
• AJMALINE — Myocardiodepressant; Root
• AJMALINE — Neurotoxic; Root
• AJMALININE — Nephrovasodilator; Root
• ARICINE — Cytotoxic; Leaf; IC50=>100 ug/ml
• ISORESERPILINE — Cardiotoxic; Leaf
• RESERPINE — Abortifacient; Root; 0.04 mg/kg ipr? rbt
• RESERPINE — Anticonvulsant; Root
• RESERPINE — Hepatoprotective; Root
• RESERPINE — Teratogenic; Root; 1-2 mg/kg ims ipr rat
• STIGMASTEROL — Antihepatotoxic; Root
• YOHIMBINE — Cardiotonic; Plant
• YOHIMBINE — Cardiovascular; Plant; 1 mg/kg ivn rat