Stephania japonica (Japanese Tape-Vine)

Traditional uses

Elsewhere

  • Astringent
  • Fever
  • Tumor
  • Urogenital

Japan

  • Cancer

Philippines

  • Itch

Chemicals

Plant

  • AKNADICINE
  • AKNADININE
  • CYCLEANINE
  • CYCLANOLINE
  • EPISTEPHAMIERSINE
  • HASUBANONINE
  • HERNANDOLINE
  • INSULARINE
  • OBAMEGINE
  • 16-OXOHASUBONINE
  • OXOSTEPHAMIERSINE
  • STEBISIMINE
  • STEPHANABERRINE
  • STEPHASUNOLINE
  • OXOSTEPHANINE
  • STEPHAMIERSINE
  • STEPISIMINE
  • AKNADINE
  • HYPOEPISTEPHANINE
  • ISOTRILOBINE
  • 16-OXOPROTOMETAPHANINE
  • PROTOSTEPHANABERRINE
  • STEPHABENINE

Stem

  • ALKALOIDS — 600
  • EPISTEPHANINE
  • HOMOSTEPHANOLINE
  • METAPHANINE
  • PROMETAPHANINE
  • STEPHANINE
  • HOMOEPISTEPHANINE
  • N-NOR-1,2-DEHYDROEPISTEPHANINE
  • STEPHANOLINE
  • DEHYDROEPISTEPHANINE
  • PROTOSTEPHANINE

Leaf

  • ISOCHONDRODENDRINE
  • PLASTOQUINONE
  • L-QUERCITOL — 4000
  • D-TETRANDRINE
  • D-FANGCHINOLINE
  • VIBURNITOL — 4000

Root

  • STEPONINE
  • STEPINONINE
  • ALKALOIDS — 27200
  • STEPHOLINE

Rhizome

  • ALKALOIDS — 25000

Activities

  1. Antiaggregant — 2 compounds; CYCLEANINE, ISOTRILOBINE
  2. Antiinflammatory — 2 compounds; CYCLEANINE, ISOTRILOBINE
  3. Antimalarial — 2 compounds; ISOCHONDRODENDRINE, OBAMEGINE
  4. Cytotoxic — 2 compounds; toxic activity; CYCLEANINE, EPISTEPHANINE
  5. Hypotensive — 2 compounds; CYCLEANINE, OBAMEGINE
  6. Pesticide — 2 compounds; AKNADICINE, OBAMEGINE
  7. Protisticide — 2 compounds; CYCLEANINE, OBAMEGINE
  8. Analgesic — 1 compounds; CYCLEANINE
  9. Antialopecic — 1 compounds; CYCLEANINE
  10. Antiarthritic — 1 compounds; CYCLEANINE
  11. Anticarcinomic — 1 compounds; toxic activity; D-TETRANDRINE
  12. Antidandruff — 1 compounds; CYCLEANINE
  13. Antileishmanic — 1 compounds; CYCLEANINE
  14. Antiplasmodial — 1 compounds; ISOCHONDRODENDRINE
  15. Antipyretic — 1 compounds; CYCLEANINE
  16. Antiseptic — 1 compounds; AKNADICINE
  17. Antisilicotic — 1 compounds; CYCLEANINE
  18. Antispasmodic — 1 compounds; AKNADINE
  19. Antitumor — 1 compounds; CYCLEANINE
  20. Dopamine-Receptor-Inhibitor — 1 compounds; CYCLEANINE
  21. Ganglionic-Blocker — 1 compounds; CYCLEANINE
  22. Hepatoprotective — 1 compounds; toxic activity; CYCLEANINE
  23. Myorelaxant — 1 compounds; CYCLEANINE
  24. Uterosedative — 1 compounds; AKNADINE

Toxic compounds

  • CYCLEANINE — Cytotoxic; Plant; 12 ppm
  • CYCLEANINE — Hepatoprotective; Plant; 10 mg/kg
  • D-TETRANDRINE — Anticarcinomic; Leaf; ED50=170 ppb
  • EPISTEPHANINE — Cytotoxic; Stem; 14 ppm