Strophanthus kombe (Kombe Arrow Poison)

Traditional uses

Africa

  • Cardiotonic
  • Diuretic
  • Poison(Arrow)
  • Stimulant

India

  • Heart

Africa(Swahili)

  • Poison
  • Poison(Arrow)

Chemicals

Seed

  • CARDENOLIDES — 70000 to 100000
  • CYMAROSE
  • EMICYMARIN
  • HELVETICOSIDE
  • NEOGLUCOERYSIMOSIDE
  • PERIPLOGENIN
  • STROPHANTHIDIN
  • STROPHANTHIDIN-GLYCOSIDE
  • STROPHANTHIDOL
  • STROPHANTHIDOL-DIGITOXOSIDO-GLUCOSIDE
  • K-STROPHANTHIN-BETA
  • 17-BETA-H-STROPHANTHOSIDE
  • STROPHANTHOSIDE-19-CARBOXYLIC-ACID
  • TRIGONELLINE
  • K-STROPHANTHOL-GAMMA
  • ALLO-CYMARIN
  • CYMAROL
  • ERYSIMOL
  • GLUCOHELVETICOSIDE
  • PERIPLOCYMARIN
  • STROPHANTHIDIOL
  • K-STROPHANTHOSIDE
  • CYMARIN — 2400

Plant

  • ERYSIMOSIDE
  • ERYSIMOSOL
  • GLUCOCYMAROL
  • ISOEMICYMARIN
  • ISOPERIPLOCYMARIN
  • PANSTROSIDE
  • MUSAROSIDE

Activities

  1. Cardiotonic — 4 compounds; toxic activity; CYMARIN, ERYSIMOSIDE, HELVETICOSIDE, PERIPLOCYMARIN
  2. Anticarcinomic — 3 compounds; toxic activity; CYMARIN, K-STROPHANTHOSIDE, STROPHANTHIDIN
  3. Cardiac — 2 compounds; CYMAROL, STROPHANTHIDIN
  4. Pesticide — 2 compounds; CYMARIN, TRIGONELLINE
  5. Antianginal — 1 compounds; STROPHANTHIDIN
  6. Antiasthmatic — 1 compounds; STROPHANTHIDIN
  7. Anticancer (Cervix) — 1 compounds; TRIGONELLINE
  8. Anticancer (Liver) — 1 compounds; TRIGONELLINE
  9. Antiedemic — 1 compounds; STROPHANTHIDIN
  10. Antihyperglycemic — 1 compounds; TRIGONELLINE
  11. Antimigraine — 1 compounds; TRIGONELLINE
  12. Antiseptic — 1 compounds; TRIGONELLINE
  13. Antitumor — 1 compounds; STROPHANTHIDIN
  14. Antitumor (Cervix) — 1 compounds; TRIGONELLINE
  15. Antitumor (Liver) — 1 compounds; TRIGONELLINE
  16. Digitalic — 1 compounds; K-STROPHANTHOSIDE
  17. Epidermal-Stimulant — 1 compounds; TRIGONELLINE
  18. Hypocholesterolemic — 1 compounds; TRIGONELLINE
  19. Hypoglycemic — 1 compounds; TRIGONELLINE
  20. Mutagenic — 1 compounds; toxic activity; TRIGONELLINE
  21. Myocardiotonic — 1 compounds; toxic activity; CYMARIN
  22. Myotonic — 1 compounds; CYMARIN
  23. Osmoregulator — 1 compounds; TRIGONELLINE
  24. Propecic — 1 compounds; TRIGONELLINE
  25. Toxic — 1 compounds; toxic activity; CARDENOLIDES
  26. Vasodilator — 1 compounds; CYMARIN

Toxic compounds

  • CARDENOLIDES — Toxic; Seed; LD50=<50 mg/kg ipr mus
  • CYMARIN — Anticarcinomic; Seed; ED50=3.9 ppb
  • CYMARIN — Cardiotonic; Seed
  • CYMARIN — Myocardiotonic; Seed
  • ERYSIMOSIDE — Cardiotonic; Plant
  • HELVETICOSIDE — Cardiotonic; Seed
  • K-STROPHANTHOSIDE — Anticarcinomic; Seed; ED50=30 ppb
  • PERIPLOCYMARIN — Cardiotonic; Seed
  • STROPHANTHIDIN — Anticarcinomic; Seed; ED50=0.24
  • TRIGONELLINE — Mutagenic; Seed