Uncaria guianensis (Cat's Claw)

Traditional uses

Guiana

• Dysentery

Chemicals

Root

• MITRAPHYLLINE
• PTEROPODINE
• SPECIOPHYLLINE
• EPICATECHIN
• PROANTHOCYANIDIN-A1
• PROANTHOCYANIDIN-B1
• PROANTHOCYANIDIN-B2
• PROANTHOCYANIDIN-B4
• UNCARINE

Bark

• QUINOVIC ACID-3-BETA-D-[BETA-D-GLUCOSYL-(1-3)-BETA-D-FUCOPYRANOSYL]-(27-1)-BETA-D-GLUCOSYL ESTER — 125
• QUINOVIC-ACID-3BETA-O-BETA-D-FUCOPYRANOSIDE — 60
• QUINOVIC ACID-3-BETA-O-BETA-D-FUCOPYRANOSYL-(27-1)-BETA-D-GLUCOSIDE — 75
• QUINOVIC-ACID-3BETA-O-BETA-D-QUINOVOPYRANOSIDE — 75
• CHLOROGENIC-ACID
• RUTIN

Leaf

• RHYNCHOPHYLLINE
• ANGUSTINE
• ANGUSTOLINE
• DIHYDROCORYNANTHEINE
• DIHYDROKAEMPFEROL
• HETEROYOHIMBINES
• HIRSUTEINE
• HIRSUTINE
• INDOLE
• ISOMITRAPHYLLINE
• ISOMITRAPHYLLINE-N-OXIDE
• ISORHYNCHOPHYLLINE
• ISORHYNCHOPHYLLINE-N-OXIDE
• KAEMPFEROL
• MITRAPHYLLINE
• OXINDOLE
• RHYNCHOPHYLLINE-N-OXIDE
• ALKALOIDS — 1400

Plant

• UNCARINE-F

Stem Bark

• ANGUSTINE
• DIHYDROCORYNANTHEINE
• HIRSUTEINE
• HIRSUTINE
• ISOPTEROPODINE
• ISORHYNCHOPHYLLINE
• ISORHYNCHOPHYLLINE-N-OXIDE
• MITRAPHYLLINE
• QUINOVIC-ACID-3BETA-O-BETA-D-FUCOPYRANOSIDE
• QUINOVIC-ACID-3BETA-O-BETA-D-FUCOPYRANOSYL-(27->1)BETA-D-GLUCOPYRANOSYLESTER — 82
• QUINOVIC-ACID-3BETA-O-(BETA-D-GLUCOPYRANOSYL-(1->3)BETA-D-FUCOPYRANOSYL-(27->1)BETA-D-GLUCOPYRANOSYLESTER — 135
• QUINOVIC-ACID-3BETA-O-BETA-D-QUINOVOPYRANOSIDE — 82
• RHYNCHOPHYLLINE
• SPECIOPHYLLINE

Root Bark

• MITRAPHYLLINE
• PTEROPODINE

Activities

1. Antihypertensive — 7 compounds; DIHYDROCORYNANTHEINE, HETEROYOHIMBINES, HIRSUTINE, ISORHYNCHOPHYLLINE, MITRAPHYLLINE, RHYNCHOPHYLLINE, RUTIN
2. Antileukemic — 7 compounds; EPICATECHIN, ISOMITRAPHYLLINE, ISOPTEROPODINE, KAEMPFEROL, MITRAPHYLLINE, SPECIOPHYLLINE, UNCARINE-F
3. Vasodilator — 7 compounds; HIRSUTEINE, HIRSUTINE, ISORHYNCHOPHYLLINE, KAEMPFEROL, MITRAPHYLLINE, RHYNCHOPHYLLINE, RUTIN
4. Antioxidant — 6 compounds; CHLOROGENIC-ACID, EPICATECHIN, ISORHYNCHOPHYLLINE, KAEMPFEROL, RHYNCHOPHYLLINE, RUTIN
5. Hypotensive — 6 compounds; DIHYDROCORYNANTHEINE, ISORHYNCHOPHYLLINE, KAEMPFEROL, MITRAPHYLLINE, RHYNCHOPHYLLINE, RUTIN
6. Pesticide — 6 compounds; CHLOROGENIC-ACID, EPICATECHIN, INDOLE, KAEMPFEROL, MITRAPHYLLINE, RUTIN
7. Antibacterial — 5 compounds; CHLOROGENIC-ACID, EPICATECHIN, INDOLE, KAEMPFEROL, RUTIN
8. Antiradicular — 5 compounds; CHLOROGENIC-ACID, ISORHYNCHOPHYLLINE, KAEMPFEROL, RHYNCHOPHYLLINE, RUTIN
9. Cancer-Preventive — 5 compounds; CHLOROGENIC-ACID, EPICATECHIN, INDOLE, KAEMPFEROL, RUTIN
10. Immunostimulant — 5 compounds; CHLOROGENIC-ACID, ISOMITRAPHYLLINE, ISOPTEROPODINE, ISORHYNCHOPHYLLINE, MITRAPHYLLINE
11. Aldose-Reductase-Inhibitor — 4 compounds; CHLOROGENIC-ACID, INDOLE, KAEMPFEROL, RUTIN
12. Antiaggregant — 4 compounds; EPICATECHIN, KAEMPFEROL, RHYNCHOPHYLLINE, RUTIN
13. Antiinflammatory — 4 compounds; CHLOROGENIC-ACID, EPICATECHIN, KAEMPFEROL, RUTIN
14. Antimutagenic — 4 compounds; toxic activity; CHLOROGENIC-ACID, EPICATECHIN, KAEMPFEROL, RUTIN
15. Antitumor — 4 compounds; CHLOROGENIC-ACID, KAEMPFEROL, PTEROPODINE, RUTIN
16. Antiviral — 4 compounds; CHLOROGENIC-ACID, EPICATECHIN, KAEMPFEROL, RUTIN
17. Calcium-Antagonist — 4 compounds; HIRSUTEINE, HIRSUTINE, ISORHYNCHOPHYLLINE, RHYNCHOPHYLLINE
18. Lipoxygenase-Inhibitor — 4 compounds; CHLOROGENIC-ACID, EPICATECHIN, KAEMPFEROL, RUTIN
19. Neuroprotective — 4 compounds; toxic activity; HIRSUTEINE, HIRSUTINE, ISORHYNCHOPHYLLINE, KAEMPFEROL
20. Phagocytotic — 4 compounds; ISOMITRAPHYLLINE, ISOPTEROPODINE, ISORHYNCHOPHYLLINE, PTEROPODINE
21. Protisticide — 4 compounds; KAEMPFEROL, MITRAPHYLLINE, RHYNCHOPHYLLINE, RUTIN
22. Allelochemic — 3 compounds; CHLOROGENIC-ACID, EPICATECHIN, RUTIN
23. Antiarrhythmic — 3 compounds; DIHYDROCORYNANTHEINE, HIRSUTINE, ISORHYNCHOPHYLLINE
24. Antidementia — 3 compounds; ISORHYNCHOPHYLLINE, RHYNCHOPHYLLINE, RUTIN
25. Antidiabetic — 3 compounds; CHLOROGENIC-ACID, EPICATECHIN, RUTIN
26. Antifeedant — 3 compounds; CHLOROGENIC-ACID, EPICATECHIN, RUTIN
27. Antiherpetic — 3 compounds; CHLOROGENIC-ACID, KAEMPFEROL, RUTIN
28. Antihistaminic — 3 compounds; CHLOROGENIC-ACID, KAEMPFEROL, RUTIN
29. Antiperoxidant — 3 compounds; CHLOROGENIC-ACID, EPICATECHIN, RUTIN
30. Antiseptic — 3 compounds; CHLOROGENIC-ACID, INDOLE, KAEMPFEROL
31. Antitumor-Promoter — 3 compounds; CHLOROGENIC-ACID, KAEMPFEROL, RUTIN
32. Antiulcer — 3 compounds; CHLOROGENIC-ACID, KAEMPFEROL, RUTIN
33. Hepatoprotective — 3 compounds; toxic activity; CHLOROGENIC-ACID, KAEMPFEROL, RUTIN
34. Myocontractant — 3 compounds; HIRSUTINE, MITRAPHYLLINE, RHYNCHOPHYLLINE
35. (-)-Chronotropic — 2 compounds; DIHYDROCORYNANTHEINE, HIRSUTINE
36. Anesthetic — 2 compounds; MITRAPHYLLINE, RHYNCHOPHYLLINE
37. Antiallergic — 2 compounds; KAEMPFEROL, RUTIN
38. Antiatherosclerotic — 2 compounds; CHLOROGENIC-ACID, RUTIN
39. Anticancer — 2 compounds; KAEMPFEROL, RUTIN
40. AntiEBV — 2 compounds; CHLOROGENIC-ACID, EPICATECHIN
41. Antiexcitotoxic — 2 compounds; toxic activity; ISORHYNCHOPHYLLINE, RHYNCHOPHYLLINE
42. Antihepatotoxic — 2 compounds; toxic activity; CHLOROGENIC-ACID, RUTIN
43. AntiHIV — 2 compounds; CHLOROGENIC-ACID, EPICATECHIN
44. Antiischemic — 2 compounds; ISORHYNCHOPHYLLINE, RHYNCHOPHYLLINE
45. Antimalarial — 2 compounds; DIHYDROCORYNANTHEINE, RUTIN
46. Antispasmodic — 2 compounds; KAEMPFEROL, RUTIN
47. Antisunburn — 2 compounds; CHLOROGENIC-ACID, RUTIN
48. Antithyroid — 2 compounds; CHLOROGENIC-ACID, RUTIN
49. Apoptotic — 2 compounds; KAEMPFEROL, RUTIN
50. cAMP-Phosphodiesterase-Inhibitor — 2 compounds; KAEMPFEROL, RUTIN
51. Carcinogenic — 2 compounds; toxic activity; INDOLE, KAEMPFEROL
52. Cardiodepressant — 2 compounds; toxic activity; MITRAPHYLLINE, RHYNCHOPHYLLINE
53. Chemopreventive — 2 compounds; CHLOROGENIC-ACID, RUTIN
54. Choleretic — 2 compounds; CHLOROGENIC-ACID, KAEMPFEROL
55. CNS-Depressant — 2 compounds; ISORHYNCHOPHYLLINE, MITRAPHYLLINE
56. Cytotoxic — 2 compounds; toxic activity; KAEMPFEROL, PTEROPODINE
57. Diuretic — 2 compounds; CHLOROGENIC-ACID, KAEMPFEROL
58. Dopaminergic — 2 compounds; HIRSUTINE, RHYNCHOPHYLLINE
59. Fungicide — 2 compounds; CHLOROGENIC-ACID, KAEMPFEROL
60. Hypocholesterolemic — 2 compounds; EPICATECHIN, RUTIN
61. Hypoglycemic — 2 compounds; CHLOROGENIC-ACID, EPICATECHIN
62. Insectiphile — 2 compounds; INDOLE, RUTIN
63. Juvabional — 2 compounds; CHLOROGENIC-ACID, RUTIN
64. Larvistat — 2 compounds; CHLOROGENIC-ACID, RUTIN
65. Mutagenic — 2 compounds; toxic activity; KAEMPFEROL, RUTIN
66. Myorelaxant — 2 compounds; MITRAPHYLLINE, RUTIN
67. NO-Inhibitor — 2 compounds; EPICATECHIN, KAEMPFEROL
68. Oviposition-Stimulant — 2 compounds; CHLOROGENIC-ACID, RUTIN
69. PAF-Inhibitor — 2 compounds; KAEMPFEROL, RUTIN
70. Sedative — 2 compounds; ISORHYNCHOPHYLLINE, RHYNCHOPHYLLINE
71. Sunscreen — 2 compounds; CHLOROGENIC-ACID, RUTIN
72. TNF-alpha-Inhibitor — 2 compounds; EPICATECHIN, KAEMPFEROL
73. Topoisomerase-II-Inhibitor — 2 compounds; KAEMPFEROL, RUTIN
74. 11B-HSD-Inhibitor — 1 compounds; KAEMPFEROL
75. 5-HT-Inhibitor — 1 compounds; RUTIN
76. 5-Lipoxygenase-Inhibitor — 1 compounds; KAEMPFEROL
77. Adrenergic-Blocker — 1 compounds; DIHYDROCORYNANTHEINE
78. Aldehyde-Oxidase-Inhibitor — 1 compounds; RUTIN
79. Allergenic — 1 compounds; toxic activity; CHLOROGENIC-ACID
80. Anabolic — 1 compounds; EPICATECHIN
81. Analgesic — 1 compounds; CHLOROGENIC-ACID
82. Antiacne — 1 compounds; INDOLE
83. Antiaflatoxin — 1 compounds; KAEMPFEROL
84. Antianaphylactic — 1 compounds; EPICATECHIN
85. Antiapoplectic — 1 compounds; RUTIN
86. Antiatherogenic — 1 compounds; RUTIN
87. Anticancer (Colon) — 1 compounds; CHLOROGENIC-ACID
88. Anticancer (Forestomach) — 1 compounds; CHLOROGENIC-ACID
89. Anticancer (Liver) — 1 compounds; CHLOROGENIC-ACID
90. Anticancer (Skin) — 1 compounds; CHLOROGENIC-ACID
91. Anticapillary-Fragility — 1 compounds; RUTIN
92. Anticarcinogenic — 1 compounds; toxic activity; CHLOROGENIC-ACID
93. Anticariogenic — 1 compounds; INDOLE
94. Anticataract — 1 compounds; RUTIN
95. Anticlastogen — 1 compounds; RUTIN
96. Anticomplementary — 1 compounds; EPICATECHIN
97. Anticonvulsant — 1 compounds; toxic activity; RUTIN
98. AntiCVI — 1 compounds; RUTIN
99. Antidermatitic — 1 compounds; toxic activity; RUTIN
100. Antiedemic — 1 compounds; RUTIN
101. Antierythemic — 1 compounds; RUTIN
102. Antifertility — 1 compounds; KAEMPFEROL
103. Antigenotoxic — 1 compounds; toxic activity; CHLOROGENIC-ACID
104. Antigingivitic — 1 compounds; KAEMPFEROL
105. Antiglaucomic — 1 compounds; RUTIN
106. Antigonadotropic — 1 compounds; CHLOROGENIC-ACID
107. Antihematuric — 1 compounds; RUTIN
108. Antihemolytic — 1 compounds; CHLOROGENIC-ACID
109. Antihemorrhoidal — 1 compounds; RUTIN
110. Antihepatitic — 1 compounds; EPICATECHIN
111. Antihypercholesterolemic — 1 compounds; CHLOROGENIC-ACID
112. Antihyperglycemic — 1 compounds; EPICATECHIN
113. Antihyperthyroid — 1 compounds; CHLOROGENIC-ACID
114. Antiimplantation — 1 compounds; KAEMPFEROL
115. AntiLegionella — 1 compounds; CHLOROGENIC-ACID
116. Antileukotriene — 1 compounds; CHLOROGENIC-ACID
117. Antilipoperoxidant — 1 compounds; EPICATECHIN
118. Antilymphocytic — 1 compounds; KAEMPFEROL
119. Antimelanogenic — 1 compounds; CHLOROGENIC-ACID
120. Antimelanomic — 1 compounds; RUTIN
121. Antimetastatic — 1 compounds; RUTIN
122. Antinephritic — 1 compounds; RUTIN
123. Antinitrosaminic — 1 compounds; CHLOROGENIC-ACID
124. Antinociceptive — 1 compounds; RUTIN
125. Antiperiodontic — 1 compounds; KAEMPFEROL
126. Antiplaque — 1 compounds; KAEMPFEROL
127. Antiplasmodial — 1 compounds; DIHYDROCORYNANTHEINE
128. Antiplatelet — 1 compounds; RUTIN
129. Antipolio — 1 compounds; CHLOROGENIC-ACID
130. Antiproliferant — 1 compounds; RUTIN
131. Antiprotozoal — 1 compounds; RUTIN
132. Antipurpuric — 1 compounds; RUTIN
133. Antipyretic — 1 compounds; RHYNCHOPHYLLINE
134. Antisalmonella — 1 compounds; INDOLE
135. Antiserotonin — 1 compounds; KAEMPFEROL
136. Antistaphylococcic — 1 compounds; KAEMPFEROL
137. Antistreptococcic — 1 compounds; INDOLE
138. Antithrombogenic — 1 compounds; RUTIN
139. Antithrombotic — 1 compounds; RHYNCHOPHYLLINE
140. Antitrypanosomic — 1 compounds; RUTIN
141. Antitumor (Colon) — 1 compounds; CHLOROGENIC-ACID
142. Antitumor (Forestomach) — 1 compounds; CHLOROGENIC-ACID
143. Antitumor (Liver) — 1 compounds; CHLOROGENIC-ACID
144. Antitumor (Skin) — 1 compounds; CHLOROGENIC-ACID
145. Antivaricose — 1 compounds; RUTIN
146. Aromatase-Inhibitor — 1 compounds; KAEMPFEROL
147. Autotoxic — 1 compounds; toxic activity; CHLOROGENIC-ACID
148. Calcium-Blocker — 1 compounds; RHYNCHOPHYLLINE
149. Capillariprotective — 1 compounds; RUTIN
150. Cardioprotective — 1 compounds; toxic activity; CHLOROGENIC-ACID
151. Cardiotonic — 1 compounds; toxic activity; EPICATECHIN
152. Catabolic — 1 compounds; RUTIN
153. Cholagogue — 1 compounds; CHLOROGENIC-ACID
154. Choline-Sparing — 1 compounds; EPICATECHIN
155. Clastogenic — 1 compounds; CHLOROGENIC-ACID
156. CNS-Active — 1 compounds; CHLOROGENIC-ACID
157. CNS-Stimulant — 1 compounds; CHLOROGENIC-ACID
158. Collagen-Sparing — 1 compounds; CHLOROGENIC-ACID
159. Copper-Chelator — 1 compounds; KAEMPFEROL
160. COX-2-Inhibitor — 1 compounds; KAEMPFEROL
161. Cyclooxygenase-Inhibitor — 1 compounds; KAEMPFEROL
162. Cytoprotective — 1 compounds; RUTIN
163. Diaphoretic? — 1 compounds; KAEMPFEROL
164. Estrogenic — 1 compounds; KAEMPFEROL
165. Estrogenic? — 1 compounds; RUTIN
166. Febrifuge — 1 compounds; RHYNCHOPHYLLINE
167. Hemostat — 1 compounds; RUTIN
168. Hepatomagenic — 1 compounds; toxic activity; RUTIN
169. Hepatotropic — 1 compounds; toxic activity; EPICATECHIN
170. Histamine-Inhibitor — 1 compounds; CHLOROGENIC-ACID
171. HIV-RT-Inhibitor — 1 compounds; KAEMPFEROL
172. ICAM-1-Inhibitor — 1 compounds; KAEMPFEROL
173. Immunomodulator — 1 compounds; RUTIN
174. iNOS-Inhibitor — 1 compounds; KAEMPFEROL
175. Inotropic — 1 compounds; KAEMPFEROL
176. Insecticide — 1 compounds; RUTIN
177. Insectifuge — 1 compounds; CHLOROGENIC-ACID
178. Insulinogenic — 1 compounds; EPICATECHIN
179. Interferonogenic — 1 compounds; CHLOROGENIC-ACID
180. Interleukin-1-alpha-Inhibitor — 1 compounds; EPICATECHIN
181. Interleukin-6-mRNA-Inhibitor — 1 compounds; EPICATECHIN
182. Iodothyronine-Deiodinase-Inhibitor — 1 compounds; KAEMPFEROL
183. JNK-Inhibitor — 1 compounds; KAEMPFEROL
184. Leukotriene-Inhibitor — 1 compounds; CHLOROGENIC-ACID
185. MAO-Inhibitor — 1 compounds; KAEMPFEROL
186. Metal-Chelator — 1 compounds; CHLOROGENIC-ACID
187. Myoprotective — 1 compounds; RUTIN
188. Natriuretic — 1 compounds; KAEMPFEROL
189. Nematicide — 1 compounds; INDOLE
190. Neuroparalytic — 1 compounds; toxic activity; RHYNCHOPHYLLINE
191. NO-Genic — 1 compounds; CHLOROGENIC-ACID
192. Ornithine-Decarboxylase-Inhibitor — 1 compounds; CHLOROGENIC-ACID
193. Pancreatogenic — 1 compounds; EPICATECHIN
194. Perfumery — 1 compounds; INDOLE
195. Peroxynitrite-Scavenger — 1 compounds; EPICATECHIN
196. Propecic — 1 compounds; EPICATECHIN
197. Quinone-Reductase-Inducer — 1 compounds; KAEMPFEROL
198. Radioprotective — 1 compounds; RUTIN
199. Serotonergic — 1 compounds; RHYNCHOPHYLLINE
200. Sweetener — 1 compounds; CHLOROGENIC-ACID
201. Teratologic — 1 compounds; toxic activity; KAEMPFEROL
202. Topoisomerase-I-Inhibitor — 1 compounds; KAEMPFEROL
203. Toxic — 1 compounds; toxic activity; ANGUSTINE
204. Tumorigenic — 1 compounds; INDOLE
205. Tyrosinase-Inhibitor — 1 compounds; KAEMPFEROL
206. Uterotonic — 1 compounds; RHYNCHOPHYLLINE
207. Uterotrophic — 1 compounds; KAEMPFEROL
208. Vasopressor — 1 compounds; RUTIN
209. Vulnerary — 1 compounds; CHLOROGENIC-ACID
210. Xanthine-Oxidase-Inhibitor — 1 compounds; EPICATECHIN

Toxic compounds

• ANGUSTINE — Toxic; Leaf
• ANGUSTINE — Toxic; Stem Bark
• CHLOROGENIC-ACID — Allergenic; Bark
• CHLOROGENIC-ACID — Anticarcinogenic; Bark
• CHLOROGENIC-ACID — Antigenotoxic; Bark
• CHLOROGENIC-ACID — Antihepatotoxic; Bark
• CHLOROGENIC-ACID — Antimutagenic; Bark
• CHLOROGENIC-ACID — Autotoxic; Bark
• CHLOROGENIC-ACID — Cardioprotective; Bark
• CHLOROGENIC-ACID — Hepatoprotective; Bark
• EPICATECHIN — Antimutagenic; Root
• EPICATECHIN — Cardiotonic; Root
• EPICATECHIN — Hepatotropic; Root
• HIRSUTEINE — Neuroprotective; Leaf
• HIRSUTEINE — Neuroprotective; Stem Bark
• HIRSUTINE — Neuroprotective; Leaf
• HIRSUTINE — Neuroprotective; Stem Bark
• INDOLE — Carcinogenic; Leaf
• ISORHYNCHOPHYLLINE — Antiexcitotoxic; Leaf
• ISORHYNCHOPHYLLINE — Antiexcitotoxic; Stem Bark
• ISORHYNCHOPHYLLINE — Neuroprotective; Leaf; 100-1,000 uM
• ISORHYNCHOPHYLLINE — Neuroprotective; Stem Bark; 100-1,000 uM
• KAEMPFEROL — Antimutagenic; Leaf; ID50=10-40 nM
• KAEMPFEROL — Carcinogenic; Leaf
• KAEMPFEROL — Cytotoxic; Leaf
• KAEMPFEROL — Hepatoprotective; Leaf; IC50=5.46 uM
• KAEMPFEROL — Mutagenic; Leaf
• KAEMPFEROL — Neuroprotective; Leaf
• KAEMPFEROL — Teratologic; Leaf
• MITRAPHYLLINE — Cardiodepressant; Leaf
• MITRAPHYLLINE — Cardiodepressant; Root
• MITRAPHYLLINE — Cardiodepressant; Root Bark
• MITRAPHYLLINE — Cardiodepressant; Stem Bark
• PTEROPODINE — Cytotoxic; Root
• PTEROPODINE — Cytotoxic; Root Bark
• RHYNCHOPHYLLINE — Antiexcitotoxic; Leaf
• RHYNCHOPHYLLINE — Antiexcitotoxic; Stem Bark
• RHYNCHOPHYLLINE — Cardiodepressant; Leaf
• RHYNCHOPHYLLINE — Cardiodepressant; Stem Bark
• RHYNCHOPHYLLINE — Neuroparalytic; Leaf
• RHYNCHOPHYLLINE — Neuroparalytic; Stem Bark
• RUTIN — Anticonvulsant; Bark
• RUTIN — Antidermatitic; Bark
• RUTIN — Antihepatotoxic; Bark
• RUTIN — Antimutagenic; Bark; ID50=2-5 nM
• RUTIN — Hepatomagenic; Bark; 20,000 ppm (diet) rat
• RUTIN — Hepatoprotective; Bark; 20 mg/kg rat
• RUTIN — Mutagenic; Bark