Zanthoxylum clava-herculis (Pepperbark)

Traditional uses

US

• Cancer
• Colic
• Inflammation
• Itch
• Rheumatism
• Spasm
• Tonic
• Ache(Tooth)
• Alterative
• Carminative
• Diaphoretic
• Stimulant
• Throat

US(Colonial)

• Chest
• Poultice
• Sore

Haiti

• Fever

US(Amerindian)

• Gonorrhea
• Sudorific
• Chest
• Sore
• Ache(Tooth)
• Panacea
• Poultice

Mexico

• Stimulant

Chemicals

Bark

• N-ACETYLANONAINE
• ASARININ
• BERBERINE
• ISOBUTYL-AMIDE
• HERCLAVIN
• NEOHERCULIN
• (-)-ASARININ
• (-)-PLUVIATILOL-GAMMA-GAMMA-DIMETHYL-ALLYL-ETHER
• (-)-SESAMIN
• 6-O-METHYLTYRAMINE-N-METHYL-CINNAMIDE
• CANDICINE
• CHELERYTHRINE
• CINNAMAMIDE
• HERCLAVINE
• HERCULIN
• MYRISTIC-ACID
• NEOHERCULINE
• NITIDINE
• PHYTOSTEROL
• PLUVIATILOL-GAMMA-GAMMA-DIMETHYL-ALLYL-ETHER
• RESINS
• SESAMIN
• TEMBETARINE
• XANTHOXYLIN-S

Plant

• BERBERINE
• NITIDINE
• EO — 33000
• LAURIFOLINE
• MAGNOFLORINE
• TANNINS

Root Bark

• (+)-LAURIFOLINE
• TEMBETARINE
• CANDICINE
• MAGNOFLORINE

Activities

1. Pesticide — 8 compounds; ASARININ, BERBERINE, CHELERYTHRINE, HERCULIN, MAGNOFLORINE, N-ACETYLANONAINE, NEOHERCULIN, SESAMIN
2. Antibacterial — 5 compounds; ASARININ, BERBERINE, CHELERYTHRINE, MAGNOFLORINE, SESAMIN
3. Piscicide — 4 compounds; ASARININ, N-ACETYLANONAINE, NEOHERCULIN, SESAMIN
4. Antileukemic — 3 compounds; ASARININ, NITIDINE, SESAMIN
5. Hypotensive — 3 compounds; BERBERINE, CHELERYTHRINE, MAGNOFLORINE
6. Analgesic — 2 compounds; BERBERINE, CHELERYTHRINE
7. Antiacetylcholinesterase — 2 compounds; BERBERINE, CHELERYTHRINE
8. Antiaggregant — 2 compounds; BERBERINE, CHELERYTHRINE
9. Antiinflammatory — 2 compounds; BERBERINE, CHELERYTHRINE
10. Antimitotic — 2 compounds; BERBERINE, CHELERYTHRINE
11. Antineoplastic — 2 compounds; BERBERINE, CHELERYTHRINE
12. Antioxidant — 2 compounds; MYRISTIC-ACID, SESAMIN
13. Antiseptic — 2 compounds; BERBERINE, CHELERYTHRINE
14. Antispasmodic — 2 compounds; BERBERINE, MAGNOFLORINE
15. Antitubercular — 2 compounds; ASARININ, BERBERINE
16. Antitumor — 2 compounds; CHELERYTHRINE, NITIDINE
17. Antiviral — 2 compounds; BERBERINE, CHELERYTHRINE
18. Candidicide — 2 compounds; BERBERINE, CHELERYTHRINE
19. Cytotoxic — 2 compounds; toxic activity; BERBERINE, CHELERYTHRINE
20. Fungicide — 2 compounds; BERBERINE, CHELERYTHRINE
21. Hypertensive — 2 compounds; CANDICINE, CHELERYTHRINE
22. Hypocholesterolemic — 2 compounds; BERBERINE, SESAMIN
23. Immunostimulant — 2 compounds; BERBERINE, CHELERYTHRINE
24. Insecticide-Synergist — 2 compounds; ASARININ, SESAMIN
25. Lipase-Inhibitor — 2 compounds; BERBERINE, CHELERYTHRINE
26. Nematicide — 2 compounds; CHELERYTHRINE, MYRISTIC-ACID
27. Paralytic — 2 compounds; toxic activity; CHELERYTHRINE, MAGNOFLORINE
28. Topoisomerase-I-Inhibitor — 2 compounds; CHELERYTHRINE, NITIDINE
29. Topoisomerase-II-Inhibitor — 2 compounds; BERBERINE, NITIDINE
30. Vasodilator — 2 compounds; BERBERINE, MAGNOFLORINE
31. (+)-Inotropic — 1 compounds; BERBERINE
32. 12-Lipoxygenase-Inhibitor — 1 compounds; CHELERYTHRINE
33. 5-Lipoxygenase-Inhibitor — 1 compounds; CHELERYTHRINE
34. Abortifacient — 1 compounds; toxic activity; BERBERINE
35. Adrenolytic — 1 compounds; BERBERINE
36. Allergenic — 1 compounds; toxic activity; SESAMIN
37. Amebicide — 1 compounds; BERBERINE
38. Anesthetic — 1 compounds; BERBERINE
39. Antiacne — 1 compounds; BERBERINE
40. Antiadrenergic — 1 compounds; BERBERINE
41. Antialzheimeran — 1 compounds; BERBERINE
42. Antiamnesic — 1 compounds; BERBERINE
43. Antiangiogenic — 1 compounds; BERBERINE
44. Antiarrhythmic — 1 compounds; BERBERINE
45. Antiarthritic — 1 compounds; BERBERINE
46. Antibacillus — 1 compounds; BERBERINE
47. Antibiotic — 1 compounds; BERBERINE
48. Anticancer — 1 compounds; BERBERINE
49. Anticariogenic — 1 compounds; BERBERINE
50. Antichlamydial — 1 compounds; BERBERINE
51. Anticholecystitic — 1 compounds; BERBERINE
52. Anticholera — 1 compounds; BERBERINE
53. Anticirrhotic — 1 compounds; BERBERINE
54. Anticonjunctivitic — 1 compounds; BERBERINE
55. Anticonvulsant — 1 compounds; toxic activity; BERBERINE
56. Antidiarrheic — 1 compounds; BERBERINE
57. Antidysenteric — 1 compounds; BERBERINE
58. Antiedemic — 1 compounds; BERBERINE
59. Antiendotoxic — 1 compounds; toxic activity; BERBERINE
60. Antienterotoxic — 1 compounds; toxic activity; BERBERINE
61. Antiesherichic — 1 compounds; BERBERINE
62. Antigiardial — 1 compounds; BERBERINE
63. Antiglaucomic — 1 compounds; BERBERINE
64. Antigonorrhea — 1 compounds; BERBERINE
65. Antihepatomic — 1 compounds; toxic activity; BERBERINE
66. Antihepatotic — 1 compounds; toxic activity; BERBERINE
67. Antiherpetic — 1 compounds; BERBERINE
68. Antihistaminic — 1 compounds; BERBERINE
69. Antiischemic — 1 compounds; BERBERINE
70. Antileishmanic — 1 compounds; BERBERINE
71. Antilipogenic — 1 compounds; BERBERINE
72. Antimalarial — 1 compounds; BERBERINE
73. Antimuscarinic — 1 compounds; BERBERINE
74. Antimyalgic — 1 compounds; BERBERINE
75. Antimycotic — 1 compounds; BERBERINE
76. Antinephritic — 1 compounds; BERBERINE
77. Antineuromuscular — 1 compounds; toxic activity; MAGNOFLORINE
78. Antiperistaltic — 1 compounds; BERBERINE
79. Antipharyngitic — 1 compounds; BERBERINE
80. Antiphotooxidative — 1 compounds; BERBERINE
81. Antiplasmodial — 1 compounds; BERBERINE
82. Antipneumonic — 1 compounds; BERBERINE
83. Antipyretic — 1 compounds; BERBERINE
84. Antisalmonella — 1 compounds; BERBERINE
85. Antisecretory — 1 compounds; BERBERINE
86. Antishigellic — 1 compounds; BERBERINE
87. Antispermigenic — 1 compounds; BERBERINE
88. Antistaphylococcic — 1 compounds; BERBERINE
89. Antistrep — 1 compounds; BERBERINE
90. Antisyphilitic — 1 compounds; BERBERINE
91. Antitrachomic — 1 compounds; BERBERINE
92. Antitrypanosomic — 1 compounds; BERBERINE
93. Antitumor (brain) — 1 compounds; BERBERINE
94. Antitussive — 1 compounds; CHELERYTHRINE
95. Antiulcer — 1 compounds; BERBERINE
96. Antivaginitic — 1 compounds; BERBERINE
97. Astringent — 1 compounds; BERBERINE
98. Bilirubinolytic — 1 compounds; BERBERINE
99. Calcium-Antagonist — 1 compounds; BERBERINE
100. Cancer-Preventive — 1 compounds; MYRISTIC-ACID
101. Cardiodepressant — 1 compounds; toxic activity; BERBERINE
102. Cardiotonic — 1 compounds; toxic activity; BERBERINE
103. Carminative — 1 compounds; BERBERINE
104. Cholagogue — 1 compounds; BERBERINE
105. Cholekinetic — 1 compounds; BERBERINE
106. Choleretic — 1 compounds; BERBERINE
107. CNS-Depressant — 1 compounds; MAGNOFLORINE
108. Collyrium — 1 compounds; BERBERINE
109. Cosmetic — 1 compounds; MYRISTIC-ACID
110. COX-2-Inhibitor — 1 compounds; BERBERINE
111. Curare — 1 compounds; CANDICINE
112. Curaroid — 1 compounds; MAGNOFLORINE
113. Cyclooxygenase-Inhibitor — 1 compounds; BERBERINE
114. Cytostatic — 1 compounds; SESAMIN
115. Desaturase-Inhibitor — 1 compounds; SESAMIN
116. Digestive — 1 compounds; BERBERINE
117. Diuretic — 1 compounds; BERBERINE
118. DNA-Intercalator — 1 compounds; CHELERYTHRINE
119. Emetic — 1 compounds; BERBERINE
120. Epileptigenic — 1 compounds; CANDICINE
121. Glaucomagenic — 1 compounds; BERBERINE
122. Gram(-)icide — 1 compounds; CHELERYTHRINE
123. Gram(+)icide — 1 compounds; CHELERYTHRINE
124. Hemostat — 1 compounds; BERBERINE
125. Hepatoprotective — 1 compounds; toxic activity; SESAMIN
126. Hypercholesterolemic — 1 compounds; MYRISTIC-ACID
127. Hypoglycemic — 1 compounds; BERBERINE
128. Immunosuppressant — 1 compounds; SESAMIN
129. Insecticide — 1 compounds; HERCULIN
130. Irritant — 1 compounds; toxic activity; CHELERYTHRINE
131. Juvabional — 1 compounds; SESAMIN
132. Lachrymatory — 1 compounds; BERBERINE
133. Larvicide — 1 compounds; BERBERINE
134. Leucocytogenic — 1 compounds; BERBERINE
135. Lipoxygenase-Inhibitor — 1 compounds; BERBERINE
136. Lubricant — 1 compounds; MYRISTIC-ACID
137. Molluscicide — 1 compounds; CHELERYTHRINE
138. Mutagenic — 1 compounds; toxic activity; BERBERINE
139. Mycobactericide — 1 compounds; BERBERINE
140. Mydriatic — 1 compounds; BERBERINE
141. Myocardiodepressant — 1 compounds; toxic activity; BERBERINE
142. Myorelaxant — 1 compounds; BERBERINE
143. Nicotinic — 1 compounds; CANDICINE
144. Occulotensive — 1 compounds; CHELERYTHRINE
145. PAF-Inhibitor — 1 compounds; MAGNOFLORINE
146. Phototoxic — 1 compounds; toxic activity; BERBERINE
147. Plasmodicide — 1 compounds; BERBERINE
148. Prostaglandin-Synthesis-Inhibitor — 1 compounds; BERBERINE
149. Protisticide — 1 compounds; BERBERINE
150. Respiradepressant — 1 compounds; BERBERINE
151. Respirainhibitor — 1 compounds; CHELERYTHRINE
152. Reverse-Transcriptase-Inhibitor — 1 compounds; NITIDINE
153. RNA-Depressant — 1 compounds; BERBERINE
154. RT-Inhibitor — 1 compounds; BERBERINE
155. Sedative — 1 compounds; BERBERINE
156. Sialogogue — 1 compounds; NEOHERCULIN
157. Stomachic — 1 compounds; BERBERINE
158. Tetanic — 1 compounds; CHELERYTHRINE
159. Tocopherol-Synergist — 1 compounds; SESAMIN
160. Toxic — 1 compounds; toxic activity; MAGNOFLORINE
161. Trichomonicide — 1 compounds; BERBERINE
162. Trypanocide — 1 compounds; BERBERINE
163. Uterocontractant — 1 compounds; BERBERINE
164. Uterotonic — 1 compounds; BERBERINE
165. Vagostimulant — 1 compounds; BERBERINE
166. Vasoconstrictor — 1 compounds; BERBERINE
167. Vermifuge — 1 compounds; BERBERINE
168. Vibriofuge — 1 compounds; BERBERINE

Toxic compounds

• BERBERINE — Abortifacient; Bark
• BERBERINE — Abortifacient; Plant
• BERBERINE — Anticonvulsant; Bark
• BERBERINE — Anticonvulsant; Plant
• BERBERINE — Antiendotoxic; Bark
• BERBERINE — Antiendotoxic; Plant
• BERBERINE — Antienterotoxic; Bark
• BERBERINE — Antienterotoxic; Plant
• BERBERINE — Antihepatomic; Bark
• BERBERINE — Antihepatomic; Plant
• BERBERINE — Antihepatotic; Bark
• BERBERINE — Antihepatotic; Plant
• BERBERINE — Cardiodepressant; Bark
• BERBERINE — Cardiodepressant; Plant
• BERBERINE — Cardiotonic; Bark
• BERBERINE — Cardiotonic; Plant
• BERBERINE — Cytotoxic; Bark
• BERBERINE — Cytotoxic; Plant
• BERBERINE — Mutagenic; Bark
• BERBERINE — Mutagenic; Plant
• BERBERINE — Myocardiodepressant; Bark
• BERBERINE — Myocardiodepressant; Plant
• BERBERINE — Phototoxic; Bark; 9 ppm
• BERBERINE — Phototoxic; Plant; 9 ppm
• CHELERYTHRINE — Cytotoxic; Bark
• CHELERYTHRINE — Irritant; Bark
• CHELERYTHRINE — Paralytic; Bark
• MAGNOFLORINE — Antineuromuscular; Plant; ED50=10 mg/kg
• MAGNOFLORINE — Antineuromuscular; Root Bark; ED50=10 mg/kg
• MAGNOFLORINE — Paralytic; Plant
• MAGNOFLORINE — Paralytic; Root Bark
• MAGNOFLORINE — Toxic; Plant
• MAGNOFLORINE — Toxic; Root Bark
• SESAMIN — Allergenic; Bark
• SESAMIN — Hepatoprotective; Bark; 100 mg/kg